Filtered By:
Source: PLoS Biology: Archived Table of Contents
Condition: Heart Disease
This page shows you your search results in order of date.
Order by Relevance | Date
Total 2 results found since Jan 2013.
Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease
by Qiulun Lu, Yufeng Yao, Zhenkun Hu, Changqing Hu, Qixue Song, Jian Ye, Chengqi Xu, Annabel Z. Wang, Qiuyun Chen, Qing Kenneth Wang
AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (CAD) and myocardial infarction (MI). However, the underlying mechanism for AGGF1-mediated therapeutic angiogenesis is unknown. Here, we show for the first time that AGGF1 activates autophagy, a housekeeping catabolic cellular process, in endothelial cells (ECs), HL1, H9C2, and vascular smooth muscle cells. Studies withAtg5 small interfering RNA (siRNA) and the autophagy inhibitors bafilomycin A1 (Baf) ...
Source: PLoS Biology: Archived Table of Contents - August 10, 2016 Category: Biology Authors: Qiulun Lu Source Type: research
