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GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress
CONCLUSION: According to the results of this study, GRK2 participated in cardiac hypertrophy induced by ISO by mitigating NLRP3 inflammasome and oxidative stress through the signaling of Nrf2 in H9c2 cells.PMID:37012864 | DOI:10.1016/j.intimp.2023.109957
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Jing Liu Xiaoli Li Lu Ding Wei Li Xiaolin Niu Dengfeng Gao Source Type: research

Selenium alleviates heart remodeling through Sirt1/AKT/GSK-3 β pathway
In this study, we explored the effects of selenium on heart failure and its possible mechanism. The heart failure models were induced by aortic banding and isoproterenol. H&E, TUNEL and PSR staining were performed to detect the degree of cardiomyocyte hypertrophy, apoptosis rates and heart fibrosis, respectively. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect different mRNA levels, and western blot was applied to assess the expressions of relative proteins. Immunofluorescence staining was used to evaluate α-SMA density. We first found that treatment of selenium alleviated heart fibrosis ...
Source: International Immunopharmacology - August 20, 2022 Category: Allergy & Immunology Authors: Cui Shengyu Luo Yinhua Li Yuanhong Zhao Jinbo Fang Can Xia Hao Zhang Changjiang Source Type: research

Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF- κB and Nrf2/HO-1 signaling pathways.
Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways. Int Immunopharmacol. 2020 Jun 11;85:106629 Authors: Yang S, Chu S, Ai Q, Zhang Z, Gao Y, Lin M, Liu Y, Hu Y, Li X, Peng Y, Pan Y, He Q, Chen N Abstract Microglia are the most widely equipped protective cells in the brain and play a pivotal role in the development of neurological diseases. Inflammatory response and oxidative stress are critical risk factors in the activation of microglia which may cause various neurological diseases. Higenamine (Hig), a plant-based alkal...
Source: International Immunopharmacology - June 10, 2020 Category: Allergy & Immunology Authors: Yang S, Chu S, Ai Q, Zhang Z, Gao Y, Lin M, Liu Y, Hu Y, Li X, Peng Y, Pan Y, He Q, Chen N Tags: Int Immunopharmacol Source Type: research