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Source: Journal of Neuro-Oncology
Condition: Brain Tumor

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Total 16 results found since Jan 2013.

Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells
ConclusionThis is the first study reporting the regulation ofEGFR transcription by EVI1 in GBM cells.
Source: Journal of Neuro-Oncology - October 14, 2019 Category: Cancer & Oncology Source Type: research

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis
ConclusionsIn conclusion, results of the current research suggest that a high CBX3 expression level predicts the poor prognosis for glioma patients. CBX3 can stimulate the growth of glioma U87 cells through targeting CDKN1A and CBX3 may become a novel target in the clinical treatment for glioma.
Source: Journal of Neuro-Oncology - September 8, 2019 Category: Cancer & Oncology Source Type: research

G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis
ConclusionOur data suggest G3BP1 knockdown diminishes SG formation and stimulates BZM-induced apoptosis of U87 cells in vitro, in addition to inhibiting glioblastoma-induced angiogenesis in vivo.
Source: Journal of Neuro-Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research

LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells
ConclusionlncRNA GAS5 can effectively inhibit the proliferation, migration and invasion of glioma cells and promote cell apoptosis through targeting GSTM3 expression.
Source: Journal of Neuro-Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

Activation of STAT1 by the FRK tyrosine kinase is associated with human glioma growth
ConclusionsOur findings highlighted a critical role of FRK in tumor suppression ability through promoting STAT1 activation, and provided a potential therapeutic target for glioma.
Source: Journal of Neuro-Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas
ConclusionsThe results suggest PEPT2 is an important candidate molecule in 5-ALA-mediated FGS in grade II/III gliomas. As the overexpression of PEPT2 was associated with higher PpIX fluorescence intensity, PEPT2 may improve fluorescence-guided resection in grade II/III gliomas.
Source: Journal of Neuro-Oncology - March 29, 2019 Category: Cancer & Oncology Source Type: research

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments
ConclusionsWe propose that Tpm 2.1 down-regulation facilitates GBM colonisation of the soft brain environment. This specialisation of the GBM actin cytoskeleton organisation that is highly suited to the soft brain-like environment may provide novel therapeutic targets for arresting GBM invasion.
Source: Journal of Neuro-Oncology - December 9, 2018 Category: Cancer & Oncology Source Type: research

Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors
ConclusionsThese results suggest that a subset of genes affected by differential histone modification in ATRT is involved in the detrimental effects of SMARCB1-deficiency and also relevant in the biology of ATRT.
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway
AbstractSpalt-like transcription factor 4 (SALL4), a oncogene, is known to participate in multiple carcinomas, and is up-regulated in glioma. However, its actual role and underlying mechanisms in the development of glioma remain unclear. The present study explored the molecular functions of SALL4 in promoting cell proliferation in glioma. The expression level of SALL4 in 69  human glioma samples and six non-tumor brain tissues was determined using real-time polymerase chain reaction (PCR). Then, we transfected U87 and U251 cell lines with siRNA, and assessed cellular proliferation and cell cycle to understand the function...
Source: Journal of Neuro-Oncology - September 8, 2017 Category: Cancer & Oncology Source Type: research

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells
AbstractDEP domain containing 1 (DEPDC1) is a novel oncoantigen expressed in cancer cells, which presents oncogenic activity and high immunogenicity. Although DEPDC1 has been predicted to be a useful antigen for the development of a cancer vaccine, its pathophysiological roles in glioma have not been investigated. Here, we analyzed the expression and function of DEPDC1 in malignant glioma. DEPDC1 expression in glioma cell lines, glioma tissues, and brain tumor initiating cells (BTICs) was assessed by western blot and quantitative polymerase chain reaction (PCR). The effect of DEPDC1 downregulation on cell growth and nuclea...
Source: Journal of Neuro-Oncology - May 29, 2017 Category: Cancer & Oncology Source Type: research

Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence
AbstractThe extent of 5-aminolevulinic acid (5-ALA) guided tumor resection has a determining impact in high-grade glioma and glioblastoma surgery. Yet the intensity of the 5-ALA induced fluorescence may vary within the tumor. We aimed to correlate 5-ALA induced fluorescence with the expression of epithelial growth factor receptor (EGFR) and its constitutively active version EGFRvIII in different glioblastoma (GBM) cell lines. To elucidate the role of EGFR in the metabolism of 5-ALA in GBM cell lines with variable EGFR expression status, we analyzed the activation of EGFR by its primary ligand EGF, and its downstream effect...
Source: Journal of Neuro-Oncology - May 12, 2017 Category: Cancer & Oncology Source Type: research

Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells
In this study, the role of CK2 signaling in BTIC function was examined. We found that expression of CK2α was increased in CD133+ BTICs compared to CD133− cells within the same GBM xenolines. Treatment with CX-4945, an ATP-competitive inhibitor of CK2, led to reduced expression of Sox2 and Nestin, transcription factors important for the maintenance of stem cells. Similarly, inhibition of CK2 also reduced the frequency of CD133+ BTICs over the course of 7 days, indicating a role for CK2 in BTIC persistence and survival. Importantly, using an in vitro limiting dilution assay, we found that inhibition of CK2 kinase activity...
Source: Journal of Neuro-Oncology - February 7, 2017 Category: Cancer & Oncology Source Type: research

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors
AbstractAtypical teratoid/rhabdoid tumors (ATRT) are highly malignant brain tumors arising in young children. The majority of ATRT is characterized by inactivation of the chromatin remodeling complex member SMARCB1 (INI1/hSNF5). Little is known, however, on downstream pathways involved in the detrimental effects of SMARCB1 deficiency which might also represent targets for treatment. UsingDrosophila melanogaster and the Gal4-UAS system, modifier screens were performed in order to identify the role of SMAD dependent signaling in the lethal phenotype associated with knockdown ofsnr1, the fly homolog ofSMARCB1. Expression and ...
Source: Journal of Neuro-Oncology - January 19, 2017 Category: Cancer & Oncology Source Type: research

Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor with grave prognosis. Despite the growing understanding of the complex signaling networks responsible for the initiation and progression of GBM, many experimental therapies have fallen short of their treatment goals. In the present study, we investigated the novel molecular mechanisms responsible for synergistic action of temozolomide (TMZ) and anti-VEGF therapy in GBM cells. We tested the combined effects of TMZ and VEGF blockade in four human GBM cell lines: TMZ-sensitive U251-MG and U373-MG cells, and TMZ-resist...
Source: Journal of Neuro-Oncology - March 7, 2016 Category: Cancer & Oncology Source Type: research

Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma
In this study, we explored the possible implication of reactive oxygen species (ROS) in hypoxia-driven Stat3 activation in human glioblastoma. We found that hypoxic stress increased ROS production as well as Stat3 activation and that ROS inhibitors (diphenyleneiodonium, rotenone and myxothiazol) and an antioxidant (N-acetyl-l-cysteine) blocked Stat3 activation under hypoxic conditions. To determine a major route of ROS production, we tested whether nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) is involved in hypoxia-induced ROS production. Nox4 expression was found to be increased at both mRNA and protein le...
Source: Journal of Neuro-Oncology - August 21, 2015 Category: Cancer & Oncology Source Type: research