Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments

ConclusionsWe propose that Tpm 2.1 down-regulation facilitates GBM colonisation of the soft brain environment. This specialisation of the GBM actin cytoskeleton organisation that is highly suited to the soft brain-like environment may provide novel therapeutic targets for arresting GBM invasion.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research