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Muscone Inhibits the Excessive Inflammatory Response in Myocardial Infarction by Targeting TREM-1
Evid Based Complement Alternat Med. 2022 May 10;2022:9112479. doi: 10.1155/2022/9112479. eCollection 2022.ABSTRACTThe inhibitory effect of muscone on the hyperinflammatory response after myocardial ischemia reperfusion injury (MIRI) was investigated, and the target and signal pathways of muscone were explored. The levels of inflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor alpha were detected through qRT-PCR and ELISA. The expression levels of p38 and NF-κB signaling pathway-related proteins were detected through Western blot. TREM-1 siRNA was transfected into macrophages in vitro. The rat m...
Source: Evidence-based Complementary and Alternative Medicine - May 20, 2022 Category: Complementary Medicine Authors: Hong Zhang Jian Ye Xu Wang Zongjun Liu Tao Chen Junqing Gao Source Type: research

The Protective Effect of Total Flavones from Rhododendron simsii Planch. on Myocardial Ischemia/Reperfusion Injury and Its Underlying Mechanism.
Conclusions: The results indicate that the protective effect of TFR on I/R injury may be correlated with its blocking UTR and the subsequent inhibition of RhoA/ROCK signaling pathway. PMID: 29541143 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - March 17, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research