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HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells
CONCLUSION: H/R induces pyroptosis via the HSP90/EZH2/miR-22/NLRP3 signaling axis in endothelial cells.PMID:37360624 | PMC:PMC10289174 | DOI:10.2147/JIR.S403531
Source: Cell Research - June 26, 2023 Category: Cytology Authors: Paihe Deng Huimin Hu Source Type: research

Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
J Bioenerg Biomembr. 2022 Dec 23. doi: 10.1007/s10863-022-09954-3. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a major cause of poor hemodynamic reconstitution outcomes after myocardial infarction or circulatory arrest. Currently, the search for effective therapeutic agents and tools is a focus of research in the field of myocardial I/R injury. Resveratrol (Res) has been extensively studied in recent years because of its good cardiovascular therapeutic effects, but its specific mechanism of action has not been fully elucidated. Therefore, the aim of this study was to investigate the mechan...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Hao Tian Yonghong Xiong Zhongyuan Xia Source Type: research

Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease
CONCLUSION: The lncRNA MIAT is involved in HS-induced pyroptosis and apoptosis and the inflammatory response of HCECs and provides a new understanding of the pathogenesis of dry eye.PMID:35676970 | PMC:PMC9169976 | DOI:10.2147/JIR.S361541
Source: Cell Research - June 9, 2022 Category: Cytology Authors: Jinjian Li Kun Yang Xinghui Pan Hui Peng Chenting Hou Jie Xiao Qing Wang Source Type: research

Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction
Nat Cardiovasc Res. 2022 Apr;1(4):372-388. doi: 10.1038/s44161-022-00047-3. Epub 2022 Apr 13.ABSTRACTMyocardial infarction (MI) is a leading cause of death worldwide, largely because efficient interventions to restore cardiac function after MI are currently lacking. Here, we characterize vascular aberrancies induced by MI, and propose to target acquired endothelial cell (EC) changes to normalize vessels and promote cardiac repair after MI. Single-cell transcriptome analyses of MI-associated ECs indicates that ECs acquire mesenchymal gene signature that result in phenotypic and functional changes and lead to vessel abnormal...
Source: Cell Research - May 16, 2022 Category: Cytology Authors: Menggui Huang Fan Yang Duo Zhang Maohuan Lin Hao Duan Rakan El-Mayta Lin Zhang Ling Qin Swapnil V Shewale Liming Pei Michael J Mitchell Daniel J Rader Yi Fan Yanqing Gong Source Type: research

Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis
CONCLUSION: The current findings reveal that sevoflurane preconditioned MSCs boost angiogenesis in HUVECs subjected to H/R insult and attenuate myocardial I/R injury, which may be mediated by TRPC6 up-regulated HIF-1α, CXCR4 and VEGF.PMID:34809715 | DOI:10.1186/s13287-021-02649-3
Source: Cell Research - November 23, 2021 Category: Cytology Authors: Jinting Yang Lihui Tang Fengjiang Zhang Tingting Yang Ting Lu Kai Sun Na Sun Jinxuan Ren Min Yan Source Type: research