• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain
CONCLUSIONS: These findings suggest that reduction of SIRT1-mediated epigenetic upregulation of Nav1.7 in the DRG contributes to the development of oxaliplatin-induced neuropathic pain in rats. The intrathecal drug delivery treatment of activating SIRT1 might be a novel therapeutic option for oxaliplatin-induced neuropathic pain.PMID:37192244
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Ling-Jun Xu Jing Wang Gui-Dan Li Kai-Feng Shen Xing-Hui He Wei Wu Cui-Cui Liu Source Type: research

Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs
Cisplatin and oxaliplatin are among the most widely used anticancer drugs in both children and adults. The clinical use of these agents is associated with dose-limiting damage to kidneys (nephrotoxicity) and peripheral nerves (neurotoxicity). Mechanistic understanding of the underlying etiology remains incomplete and preventive strategies are currently unavailable. We previously reported that cisplatin nephrotoxicity (Filipski et al, CPT 2009) and oxaliplatin neurotoxicity (Sprowl et al, PNAS 2013) are dependent on organic cation transporter-mediated uptake mechanisms and can be reduced by genetic or pharmacological inhibi...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Pabla, N., Sprowl, J. A., Ong, S. S., Gibson, A. A., Du, G., Lin, W., Hu, S., Li, L., Chen, T., Sparreboom, A. Tags: Experimental and Molecular Therapeutics Source Type: research