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Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking
Publication date: Available online 1 February 2017 Source:Molecular and Cellular Neuroscience Author(s): Amar N. Kar, Jose Norberto S. Vargas, Cai-Yun Chen, Jeffrey A Kowalak, Anthony E. Gioio, Barry B. Kaplan In previous studies, we identified a putative 38-nucleotide stem-loop structure (zipcode) in the 3′ untranslated region of the cytochrome c oxidase subunit IV (COXIV) mRNA that was necessary and sufficient for the axonal localization of the message in primary superior cervical ganglion (SCG) neurons. However, little is known about the proteins that interact with the COXIV-zipcode and regulate the axonal traffickin...
Source: Molecular and Cellular Neuroscience - February 1, 2017 Category: Neuroscience Source Type: research