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Source: European Journal of Pharmaceutics and Biopharmaceutics
Condition: Mitochondrial Disease
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Total 10 results found since Jan 2013.
Mitochondria-Targeted CoQ < sub > 10 < /sub > Loaded PLGA-b-PEG-TPP Nanoparticles: Their Effects on Mitochondrial Functions of COQ8B < sup > -/- < /sup > HK-2 cells
Eur J Pharm Biopharm. 2022 Feb 26:S0939-6411(22)00039-X. doi: 10.1016/j.ejpb.2022.02.018. Online ahead of print.ABSTRACTCoenzyme Q10 (CoQ10) deficiency exhibits signs of multiple organ dysfunctions, particular subtypes present isolated kidney involvement progressing to chronic kidney disease. In these patients, early administration of oral CoQ10 has been shown to decrease proteinuria and to delay development of chronic kidney disease, which suggests that it may have a renoprotective potential in these patients. However, CoQ10 bioavailability in mitochondria is low, therefore its efficacy is limited. We aimed to develop mit...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 1, 2022 Category: Drugs & Pharmacology Authors: Hamide Sena Ozbay Samiye Yabanoglu-Ciftci Ipek Baysal Merve Gultekinoglu Cemil Can Eylem Kezban Ulubayram Emirhan Nemutlu Rezan Topaloglu Fatih Ozaltin Source Type: research
