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Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
CONCLUSIONS: SAHH inhibition epigenetically upregulates Drp1 expression through repressing DNA methylation in endothelial cells, leading to vascular senescence and atherosclerosis. These results identify SAHH or SAH as a potential therapeutic target for vascular senescence and cardiovascular diseases.PMID:37517319 | DOI:10.1016/j.redox.2023.102828
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Yiran You Xu Chen Yu Chen Juan Pang Qian Chen Qiannan Liu Hongliang Xue Yupeng Zeng Jinghe Xiao Jiaxin Mi Yi Tang Wenhua Ling Source Type: research

Buyang huanwu decoction inhibits diabetes-accelerated atherosclerosis via reduction of AMPK-Drp1-mitochondrial fission axis
CONCLUSION: The above findings support the conclusion that BYHWD suppresses diabetes-accelerated atherosclerosis by reducing mitochondrial fission through modulation of the AMPK/Drp1 pathway.PMID:37003404 | DOI:10.1016/j.jep.2023.116432
Source: Atherosclerosis - April 1, 2023 Category: Cardiology Authors: Wanyu Tong Ling Leng Yucheng Wang Jingwen Guo Felix Boahen Owusu Yue Zhang Fang Wang Ruiqiao Li Yuhong Li Yanxu Chang Yuefei Wang Qilong Wang Source Type: research

PCSK9 Inhibitors in Cancer Patients Treated with Immune-Checkpoint Inhibitors to Reduce Cardiovascular Events: New Frontiers in Cardioncology
Cancers (Basel). 2023 Feb 22;15(5):1397. doi: 10.3390/cancers15051397.ABSTRACTCancer patients treated with immune checkpoint inhibitors (ICIs) are exposed to a high risk of atherosclerosis and cardiometabolic diseases due to systemic inflammatory conditions and immune-related atheroma destabilization. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key protein involved in metabolism of low-density lipoprotein (LDL) cholesterol. PCSK9 blocking agents are clinically available and involve monoclonal antibodies, and SiRNA reduces LDL levels in high-risk patients and atherosclerotic cardiovascular disease events in m...
Source: Atherosclerosis - March 11, 2023 Category: Cardiology Authors: Vincenzo Quagliariello Irma Bisceglia Massimiliano Berretta Martina Iovine Maria Laura Canale Carlo Maurea Vienna Giordano Andrea Paccone Alessandro Inno Nicola Maurea Source Type: research

The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research

Salvianolic Acid B Suppresses ER Stress-Induced NLRP3 Inflammasome and Pyroptosis via the AMPK/FoxO4 and Syndecan-4/Rac1 Signaling Pathways in Human Endothelial Progenitor Cells
Oxid Med Cell Longev. 2022 Mar 17;2022:8332825. doi: 10.1155/2022/8332825. eCollection 2022.ABSTRACTMounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress responses can activate the inflammasome, which generally results in endothelial dysfunction, a major pathogenetic factor of chronic inflammatory diseases such as atherosclerosis. Salvianolic acid B (SalB), produced by Radix Salviae, exerts antioxidative and anti-inflammatory activities in multiple cell types. However, SalB's effects on ER stress-related inflammasome and endothelial dysfunction remain unknown. Here, we showed SalB substantially abro...
Source: Atherosclerosis - March 28, 2022 Category: Cardiology Authors: Yubo Tang Qingde Wa Longyun Peng Yifan Zheng Jie Chen Xiao Chen Xuenong Zou Huangxuan Shen Shuai Huang Source Type: research