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Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Am J Physiol Renal Physiol. 2021 Aug 2. doi: 10.1152/ajprenal.00673.2020. Online ahead of print.ABSTRACTThe relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-induced AKI. This result was...
Source: Am J Physiol Renal P... - August 2, 2021 Category: Urology & Nephrology Authors: Rie Fujii Sho Hasegawa Hiroshi Maekawa Tsuyoshi Inoue Kentaro Yoshioka Rie Uni Yoichiro Ikeda Masaomi Nangaku Reiko Inagi Source Type: research

Effect of Forkhead Box O1 in Renal Tubular Epithelial Cells on Endotoxin-Induced Acute Kidney Injury.
In conclusion, downregulation of FOXO1 in RTECs mediated endotoxin-induced AKI and mitochondrial damage. Overexpression of FOXO1 could improve renal injury and mitochondrial dysfunction, and this effect occurred at least in part as a result of PGC1-α signaling. FOXO1 might be a potential target for the prevention and treatment of endotoxin-induced AKI. PMID: 33356954 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - December 28, 2020 Category: Urology & Nephrology Authors: Zhang M, Dong W, Li Z, Xiao Z, Xie Z, Ye Z, Liu S, Li R, Chen Y, Zhang L, Wang M, Liang H, Baihetiyaer R, Apaer R, Dong Z, Liang X Tags: Am J Physiol Renal Physiol Source Type: research

Protein Disulfide Isomerase Inhibition Impairs Keap1/Nrf2 Signaling and Mitochondrial Function and Induces Apoptosis in Renal Proximal Tubular Cells.
Abstract Renal proximal tubular apoptosis plays a critical role in kidney health and disease. However, cellular molecules that trigger renal apoptosis remain elusive. Here, we evaluated the effect of inhibiting protein disulfide isomerase (PDI), a critical thioredoxin chaperone protein, on apoptosis, and the underlying mechanisms in human renal proximal tubular (HK2) cells. HK2 cells were transfected with PDI specific siRNA in the absence and presence of an antioxidant tempol. PDI siRNA transfection resulted in a decrease of ~70% in PDI protein expression and enzyme activity. PDI inhibition increased caspase-3 act...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Pokkunuri ID, Lokhandwala MF, Banday AA Tags: Am J Physiol Renal Physiol Source Type: research

NLRP3 Deletion Protects against Renal Fibrosis and Attenuates Mitochondrial Abnormality in Mouse with 5/6 Nephrectomy.
Abstract Progressive fibrosis in chronic kidney disease (CKD) is the well-recognized cause leading to the progressive loss of renal function. Emerging evidence indicated a pathogenic role of NLRP3 inflammasome in mediating kidney injury. However, the role of NLRP3 in remnant kidney disease model is still undefined. The present study is undertaken to evaluate the function of NLRP3 in modulating renal fibrosis in a CKD model of 5/6 nephrectomy (5/6 Nx) and the potential involvement of mitochondrial dysfunction in the pathogenesis. Employing NLRP3+/+ and NLRP3-/- mice with or without 5/6 Nx, we examined renal fibroti...
Source: Am J Physiol Renal P... - February 17, 2016 Category: Urology & Nephrology Authors: Gong W, Mao S, Yu J, Song J, Jia Z, Huang S, Zhang A Tags: Am J Physiol Renal Physiol Source Type: research