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Condition: Autoimmune Disease
Therapy: Alternative and Complementary Therapies
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Total 2 results found since Jan 2013.
Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway
In this study, we examined whether the TSC treatment of RA affects the lncRNA OIP5-AS1/miR-410-3p/Wnt7b pathway.MATERIALS AND METHODS: Freund's complete adjuvant was used to create an adjuvant arthritis (AA) rat model with rat synovial cells being harvested and cultured. The experiment comprises a normal group, model group, TSC optimal-dose group, TSC optimal-dose group + lncRNA OIP5-AS1siRNA group, lncRNA OIP5-AS1 siRNA group, and lncRNA OIP5-AS1 siRNA + NC group. MMT was used to screen the optimal concentration of TSC. The level of lncRNA OIP5-AS1, miR-410-3p, Wnt7b, β-catenin, c-Myc, cyclin D1, GSK-3β, and SFRP4 mRNA ...
Source: Evidence-based Complementary and Alternative Medicine - June 7, 2022 Category: Complementary Medicine Authors: Lingyu Pan Yuan Sun Hui Jiang Yan Chen Yeke Jiang Yanquan Han Yongzhong Wang Source Type: research
