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Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
In this study, we developed high‐fat diet‐fed streptozotocin (HFD‐STZ) rat, a well‐known type 2 diabetic model, to evaluate the effect of melatonin on MI/R injury with a focus on silent information regulator 1 (SIRT1) signaling, oxidative stress, and PERK/eIF2α/ATF4‐mediated ER stress. HFD‐STZ treated rats were exposed to melatonin treatment in the presence or the absence of sirtinol (a SIRT1 inhibitor) and subjected to MI/R surgery. Compared with nondiabetic animals, type 2 diabetic rats exhibited significantly decreased myocardial SIRT1 signaling, increased apoptosis, enhanced oxidative stress, and ER stress...
Source: Journal of Pineal Research - September 11, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research

Reduced SIRT1 signaling exacerbates myocardial ischemia reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 20, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research

Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Bruno G. Teodoro, Flavia G. Baraldi, Igor H. Sampaio, Lucas H. M. Bomfim, André L. Queiroz, Madla A. Passos, Everardo M. Carneiro, Luciane C. Alberici, Ramon Gomis, Fernanda G. Amaral, José Cipolla‐Neto, Michel B Araújo, Tanes Lima, Sérgio Akira Uye Tags: Original Article Source Type: research