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Antibodies against H1N1 influenza virus hemagglutinin cross-react with prohibitin.
Abstract Influenza virus infection is associated with type 1 diabetes (T1DM), but its pathogenesis remains unclear. Here, our study found that one of the monoclonal antibodies against H1N1 influenza virus hemagglutinin(HA) cross-reacted with human pancreatic tissue and further demonstrated that it binded to rat islet β-cells. We immunoprecipitated islet protein with this cross-reactive antibody and identified the bound antigen as prohibitin by mass spectrometry. We then expressed the prohibitin protein in bacteria and confirmed the antibody binding to prohibitin by Western blot. We also verified the cross-reactiv...
Source: Biochemical and Biophysical Research communications - April 5, 2019 Category: Biochemistry Authors: Sun L, Li H, Sun J, Guo C, Feng Y, Li Y, Zhao X, Xie X, Hu J Tags: Biochem Biophys Res Commun Source Type: research