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Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration
Biochem Biophys Res Commun. 2021 Mar 16;551:148-154. doi: 10.1016/j.bbrc.2021.02.148. Online ahead of print.ABSTRACTWaste product deposition and light stress in the retinal pigment epithelium (RPE) are crucial factors in the pathogenesis of various retinal degenerative diseases, including age-related macular degeneration (AMD), a leading cause of vision loss in elderly individuals worldwide. Given that autophagy in the RPE suppresses waste accumulation, determining the molecular mechanism by which autophagy is compromised in degeneration is necessary. Using polarized human RPE sheets, we found that bis-retinoid N-retinyl-N...
Source: Biochemical and Biophysical Research communications - March 19, 2021 Category: Biochemistry Authors: Satoru Ando Noriyasu Hashida Daisuke Yamashita Tsuyoshi Kawabata Kazunobu Asao Satoshi Kawasaki Kazushi Sakurai Tamotsu Yoshimori Kohji Nishida Source Type: research

Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells.
Abstract HIF-1α is known to play an important role in the induction of VEGF by hypoxia in retinal pigment epithelial (RPE) cells. However, the involvement of the other isoform, HIF-2α, in RPE cells remains unclear. Thus, the purpose of present study was to clarify the role of HIF-2α during induction of angiogenic genes in hypoxic RPE cells. When human RPE cells (ARPE-19) were cultured under hypoxic conditions, HIF-1α and HIF-2α proteins increased. This induced an increase in mRNA for VEGF, causing secretion of VEGF protein into the medium. This conditioned medium induced tube formation in human vascular endot...
Source: Molecular and Cellular Biochemistry - July 20, 2013 Category: Biochemistry Authors: Nakajima T, Nakajima E, Shearer TR, Azuma M Tags: Mol Cell Biochem Source Type: research