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Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells.
Abstract HIF-1α is known to play an important role in the induction of VEGF by hypoxia in retinal pigment epithelial (RPE) cells. However, the involvement of the other isoform, HIF-2α, in RPE cells remains unclear. Thus, the purpose of present study was to clarify the role of HIF-2α during induction of angiogenic genes in hypoxic RPE cells. When human RPE cells (ARPE-19) were cultured under hypoxic conditions, HIF-1α and HIF-2α proteins increased. This induced an increase in mRNA for VEGF, causing secretion of VEGF protein into the medium. This conditioned medium induced tube formation in human vascular endot...
Source: Molecular and Cellular Biochemistry - July 20, 2013 Category: Biochemistry Authors: Nakajima T, Nakajima E, Shearer TR, Azuma M Tags: Mol Cell Biochem Source Type: research