• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

FTY720 ameliorates renal fibrosis by simultaneously affecting leucocyte recruitment and TGF ‐β signalling in fibroblasts
In this study, we evaluated the effect of fingolimod (FTY720), an analogue of sphingosine 1‐phosphate (S1P), as a treatment for the unilateral ureteral obstruction (UUO)‐induced renal fibrosis animal model. We treated mice with FTY720 at a dosage of 1 mg/kg/day by intragastric administration from day 1 until day 7. The control group received the same amount of saline. FTY720 reduced significantly the urine albumin/creatinine ratio (UACR) in treated UUO mice. FTY720 treatment also caused a significant decrease in interstitial expansion and collagen deposition in the kidney, accompanied by reduced mononuclear cell recrui...
Source: Clinical and Experimental Immunology - July 27, 2017 Category: Allergy & Immunology Authors: T. Tian, J. Zhang, X. Zhu, S. Wen, D. Shi, H. Zhou Tags: Original Article Source Type: research

FTY720 ameliorates renal fibrosis by simultaneously affecting leukocyte recruitment and TGF ‐β signaling in fibroblasts
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - June 28, 2017 Category: Allergy & Immunology Authors: Tongguan Tian, Jun Zhang, Xingxing Zhu, Shuang Wen, Dongyan Shi, Hong Zhou Tags: Original Article Source Type: research