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Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance
AbstractCancer has presented to be the most challenging disease, contributing to one in six mortalities worldwide. The current treatment regimen involves multiple rounds of chemotherapy administration, alone or in combination. The treatment has adverse effects including cardiomyopathy, hepatotoxicity, and nephrotoxicity. In addition, the development of resistance to chemo has been attributed to cancer relapse and low patient overall survivability. Multiple drug resistance development may be through numerous factors such as up-regulation of drug transporters, drug inactivation, alteration of drug targets and drug degradatio...
Source: Apoptosis - June 18, 2022 Category: Molecular Biology Source Type: research

Quercetin Attenuates Doxorubicin Cardiotoxicity by Modulating Bmi‐1 Expression
Conclusions And ImplicationsOur results demonstrate that QCT abrogates Dox‐induced cardiotoxicity in vitro and in vivo by reducing oxidative stress by upregulation of Bmi‐1 expression. The novel findings presented in this study have potential applications in preventing Dox‐induced cardiomyopathy.
Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Qinghua Dong, Long Chen, Qunwei Lu, Sherven Sharma, Lei Li, Sachio Morimoto, Guanyu Wang Tags: Research Paper Source Type: research