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Condition: Cardiomyopathy
Drug: Carisoprodol
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ARIA Regulates Cardiac PI3K/Akt Signals Signal Transduction
PI3K/Akt signaling plays an important role in the regulation of cardiomyocyte death machinery, which can cause stress-induced cardiac dysfunction. Here, we report that apoptosis regulator through modulating IAP expression (ARIA), a recently identified transmembrane protein, regulates the cardiac PI3K/Akt signaling and thus modifies the progression of doxorubicin (DOX)-induced cardiomyopathy. ARIA is highly expressed in the mouse heart relative to other tissues, and it is also expressed in isolated rat cardiomyocytes. The stable expression of ARIA in H9c2 cardiac muscle cells increased the levels of membrane-associated PTEN...
Source: Journal of Biological Chemistry - January 31, 2014 Category: Chemistry Authors: Kitamura, Y., Koide, M., Akakabe, Y., Matsuo, K., Shimoda, Y., Soma, Y., Ogata, T., Ueyama, T., Matoba, S., Yamada, H., Ikeda, K. Tags: Molecular Bases of Disease Source Type: research
