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IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy
CONCLUSION: Our findings demonstrate that depletion of IGF-1R lead to an increase in radiosensitivity in CRC.PMID:34092618 | DOI:10.3233/CBM-210016
Source: Cancer Biomarkers - June 7, 2021 Category: Cancer & Oncology Authors: Rui Zong Xiaoman Chen Jingjing Feng Shan Xu Source Type: research

MicroRNA-137 chemosensitizes colon cancer cells to the chemotherapeutic drug oxaliplatin (OXA) by targeting YBX1.
In this study, we utilized microRNA microarray analysis and real-time PCR to verify that miR-93, miR-191, miR-137, miR-181 and miR-491-3p were significantly down-regulated and that miR-96, miR-21, miR-22, miR-15b and miR-92 were up-regulated in both HCT-15/OXA and SW480/OXA cell lines. Blocking miR-137 caused a significant inhibition of OXA-induced cytotoxicity, therefore, miR-137 was chosen for further research. An in vitro cell viability assay showed that knockdown of miR-137 in HCT-15 and SW480 cells caused a marked inhibition of OXA-induced cytotoxicity. Moreover, we found that miR-137 was involved in repression of YBX...
Source: Cancer Biomarkers - January 1, 2017 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research