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Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway.
In this study, firstly the differential expression of Ski in OS tissues and osteochondroma tissues was detected, and the expression of Ski in both human OS cell lines (MG63 and U2OS) and normal osteoblasts (hFoB1.19) was then detected. The results demonstrated that Ski expression was significantly upregulated in both human OS tissues and cell lines. The results led us to hypothesize that Ski may play an essential role in the pathological process of OS. Thus, Ski specific small interfere RNA (Ski‑siRNA) was used. The results revealed that OS cell proliferation was markedly inhibited following the knockdown of Ski, which w...
Source: International Journal of Oncology - November 13, 2019 Category: Cancer & Oncology Authors: Zhao X, Fang Y, Wang X, Yang Z, Li D, Tian M, Kang P Tags: Int J Oncol Source Type: research

Let ‑7d inhibits colorectal cancer cell proliferation through the CST1/p65 pathway.
Let‑7d inhibits colorectal cancer cell proliferation through the CST1/p65 pathway. Int J Oncol. 2018 May 23;: Authors: Jiang J, Liu HL, Tao L, Lin XY, Yang YD, Tan SW, Wu B Abstract Cystatin SN (cystatin 1, CST1) is a member of the cystatin superfamily which inhibits the proteolytic activity of cysteine proteases. CST1 is a tumor biomarker that provides useful information for the diagnosis of esophageal, gastric and colorectal carcinomas. MicroRNAs (miRNAs or miRs) play an important role in tumor cell proliferation. However, the exact role of let‑7d and CST1 in colon cancer remains unknown. The a...
Source: International Journal of Oncology - May 23, 2018 Category: Cancer & Oncology Authors: Jiang J, Liu HL, Tao L, Lin XY, Yang YD, Tan SW, Wu B Tags: Int J Oncol Source Type: research

TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma.
We examined 149 ESCC tissue specimens to determine the clinical significance of TNFAIP3 by immunohistochemistry. Western blot analyses were used to detect TNFAIP3 expression in TE-1, TE-8, TE-15 and KYSE-70 ESCC cells and in Het-1A, a non-cancerous esophageal cell line. TNFAIP3 protein knockdown was conducted using small-interfering RNA to investigate its impact on cell proliferation, migration and invasion. Significant correlations between TNFAIP3 expression and differentiation (P=0.04) among clinicopathological characteristics of ESCC patients were demonstrated, and high TNFAIP3 expression was associated with poor survi...
Source: International Journal of Oncology - February 8, 2017 Category: Cancer & Oncology Authors: Hadisaputri YE, Miyazaki T, Yokobori T, Sohda M, Sakai M, Ozawa D, Hara K, Honjo H, Kumakura Y, Kuwano H Tags: Int J Oncol Source Type: research

Upregulation of AUF1 is involved in the proliferation of esophageal squamous cell carcinoma through GCH1.
Abstract Esophageal squamous cell carcinoma (ESCC) has one of the highest mortality rates worldwide. AU-rich element RNA-binding factor 1 (AUF1) is an established RNA-binding protein. AUF1 influences the process of development, apoptosis and tumorigenesis via interacting with adenylate-uridylate rich elements (AREs) bearing mRNAs. However, the clinical relevance of AUF1 and its biological function in ESCC progression have not been reported. In the present study, we first investigated the expression of AUF1 in the ESCC tissue samles and normal samples. We found a significantly higher expression of AUF1 in ESCC tiss...
Source: International Journal of Oncology - October 31, 2016 Category: Cancer & Oncology Authors: Gao Y, Wang W, Cao J, Wang F, Geng Y, Cao J, Xu X, Zhou J, Liu P, Zhang S Tags: Int J Oncol Source Type: research

Podoplanin-mediated TGF-β-induced epithelial-mesenchymal transition and its correlation with bHLH transcription factor DEC in TE-11 cells.
In this study, we investigated the correlation between podoplanin and EMT-related markers in esophageal squamous cell carcinoma (ESCC), and evaluated its linkage with the basic helix-loop-helix (bHLH) transcription factor differentiated embryonic chondrocyte (DEC) 1 and DEC2. Three ESCC cell lines and human squamous cell carcinoma A431 cells were subjected to western blot analyses for podoplanin and EMT markers, as well as the expression of DEC1 and DEC2. By RT-qPCR and western blotting, we found that TGF-β increased the expression of podoplanin and mensenchymal markers (e.g., N-cadherin and vimentin), while decreased th...
Source: International Journal of Oncology - March 17, 2016 Category: Cancer & Oncology Authors: Wu Y, Liu Q, Yan X, Kato Y, Tanaka M, Inokuchi S, Yoshizawa T, Morohashi S, Kijima H Tags: Int J Oncol Source Type: research