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Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells
Oncotarget. 2021 Mar 2;12(5):401-411. doi: 10.18632/oncotarget.27884. eCollection 2021 Mar 2.ABSTRACTThe glioma associated oncogene-1 (GLI1), a downstream effector of the embryonic Hedgehog pathway, was detected in chronic lymphocytic leukemia (CLL), but not normal adult cells. GLI1 activating mutations were identified in 10% of patients with CLL. However, what induces GLI1 expression in GLI1-unmutated CLL cells is unknown. Because signal transducer and activator of transcription 3 (STAT3) is constitutively activated in CLL cells and sequence analysis detected putative STAT3-binding sites in the GLI1 gene promoter, we hypo...
Source: Oncotarget - March 22, 2021 Category: Cancer & Oncology Authors: Uri Rozovski David M Harris Ping Li Zhiming Liu Preetesh Jain Taghi Manshouri Ivo Veletic Alessandra Ferrajoli Prithviraj Bose Phillip Thompson Nitin Jain Srdan Verstovsek William Wierda Michael J Keating Zeev Estrov Source Type: research

CD164 regulates proliferation, progression, and invasion of human glioblastoma cells.
Authors: Wang CC, Hueng DY, Huang AF, Chen WL, Huang SM, Yi-Hsin Chan J Abstract Grade IV astrocytoma, also known as glioblastoma multiforme (GBM), is the most common and aggressive intracranial glial tumor. GBM is associated with very poor survival and effective treatments have remained elusive so far. Mounting evidence indicates that CD164 contributes to stemness and tumorigenesis in normal cells and is overexpressed in various tumor types, including glioblastoma. Using tissue microarray immunohistochemistry, we show that there is a significant correlation between CD164 expression and glioma type and grade. Deple...
Source: Oncotarget - April 23, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors.
Conclusion: This study reports the molecular pathways and key molecules that are mediated by CECR1 function in THP- 1-derived MQs and TAMs in glioma. Methods: PMA-treated THP-1 cells (MQs) were siRNA transfected for CECR1 in vitro, with or without stimulation of the primary glioma cell line U87. Lysates were analyzed by (nano)LC-MS. Significant altered protein levels were identified (P < 0.05), followed by pathway annotation. PMID: 30323894 [PubMed]
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide.
Authors: Melamed JR, Morgan JT, Ioele SA, Gleghorn JP, Sims-Mourtada J, Day ES Abstract Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are deregulated in GBM, including Hedgehog (Hh) signaling. Here, we investigate suppression of Hh signaling as an adjuvant to TMZ using U87-MG and T98G cell lines as in vitro models of GBM. We found that silencing GLI1 with siRNA reduces cell metabolic activity by up to 30% in combination ...
Source: Oncotarget - June 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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