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Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research