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TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation
CONCLUSIONS: Our study revealed that siTIM could inhibited EGFR activation through activating AMPK and inhibiting SPHK1 expression, as well as influencing mitochondrial function and alter the ATP level; TIM's high expression in LUAD is an important factor and a potential key target in LUAD.PMID:37433364 | DOI:10.1016/j.ejphar.2023.175883
Source: European Journal of Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Houqing Yin Zequn Wang Dan Wang Muhadaisi Nuer Mengyuan Han Peng Ren Shanwu Ma Chutong Lin Jingjing Chen Haocheng Xian Dongmei Ai Xuejun Li Shaohua Ma Zhiqiang Lin Yan Pan Source Type: research

The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research

Molecular insights into the microtubules depolymerizing activity of the IL-8 receptor B antagonist SB225002
CONCLUSIONS: Findings of the present study warrants further development of SB225002 as a lead compound that uniquely targets microtubules dynamics and IL-8 signaling.PMID:35647855 | DOI:10.26355/eurrev_202205_28869
Source: Pharmacological Reviews - June 1, 2022 Category: Drugs & Pharmacology Authors: A E Goda T Sakai Source Type: research

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