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Activating transcription factor 4 regulates hypoxia inducible factor 1 α in chronic hypoxia in pancreatic cancer cells
Oncol Rep. 2023 Jan;49(1):14. doi: 10.3892/or.2022.8451. Epub 2022 Nov 23.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to adapt to low oxygen environments. Hypoxia also causes endoplasmic reticulum (ER) stress, increasing activating transcription factor 4 (ATF4), a master regulator of the unfolded protein response (UPR) pathway that mediates cellular response to ER stress. ATF4 is overexpressed in PDAC and is assoc...
Source: Oncology Reports - November 23, 2022 Category: Cancer & Oncology Authors: Nancy T Chee Candace H Carriere Zachary Miller Scott Welford Shaun P Brothers Source Type: research

Corrigendum BMI ‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor
Oncol Rep. 2022 Aug;48(2):141. doi: 10.3892/or.2022.8352. Epub 2022 Jun 22.ABSTRACTFollowing the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 5 on p. 1637, the data panel selected to represent the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. 5A appeared to overlap with the data shown for the 'JEC/+BMI‑1 siRNA/Migration' panel in Fig. 5C, such that they were potentially derived from the same original source. The authors have re‑examined their original data, and realize that the data panel selected for the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. ...
Source: Oncology Reports - June 22, 2022 Category: Cancer & Oncology Authors: Jing Yu Ling Chen Zhenhua Bao Ying Liu Guohong Liu Fengling Li Lianqin Li Source Type: research

Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3
In conclusion, our study demonstrates that NBCe1 regulates acid extrusion in prostate cancer cells and inhibiting or abolishing this transporter decreases cancer cell proliferation.PMID:34013380 | DOI:10.3892/or.2021.8080
Source: Oncology Reports - May 20, 2021 Category: Cancer & Oncology Authors: Jun Ming Li Soojung Lee Reda Zafar Eunjung Shin Inyeong Choi Source Type: research

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