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Long non ‑coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11.
Long non‑coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11. Oncol Rep. 2020 Sep;44(3):1233-1245 Authors: Huo W, Qi F, Wang K Abstract Prostate cancer is a serious threat to men's health worldwide. While previous studies have demonstrated that long non‑coding RNAs (lncRNAs) are closely associated with the initiation and development of several types of cancer, the role of lncRNAs in the progression of prostate cancer remains incompletely understood. In the present study, the lncRNA brain cytoplasmic RNA 1 (BCYRN1) was found to be overexpressed in prostate tumors compared ...
Source: Oncology Reports - July 28, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IL ‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway.
IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway. Oncol Rep. 2017 Aug 25;: Authors: Zhang JF, Wang P, Yan YJ, Li Y, Guan MW, Yu JJ, Wang XD Abstract As an important member of the interleukin (IL)-1 family, IL‑33 plays a significant role in tumor progression. To explore this, we previously analyzed the association between IL‑33 expression and the prognosis of patients with glioma. However, the function of the IL‑33/ST2 axis in glioma remained unclear. In the present study, immunofluorescent staining results revealed that the expression...
Source: Oncology Reports - August 31, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo.
In conclusion, silencing of ATM via the siRNA technique improved radiosensitivity of GSCs both in vitro and in vivo. PMID: 28560406 [PubMed - as supplied by publisher]
Source: Oncology Reports - June 2, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

siRNA-mediated inhibition of endogenous brain ‑derived neurotrophic factor gene modulates the biological behavior of HeLa cells.
siRNA-mediated inhibition of endogenous brain‑derived neurotrophic factor gene modulates the biological behavior of HeLa cells. Oncol Rep. 2017 May;37(5):2751-2760 Authors: Sun CY, Chu ZB, Huang J, Chen L, Xu J, Xu AS, Li JY, Hu Y Abstract Brain-derived neurotrophic factor (BDNF) is expressed in a number of neural and non-neuronal tumors. The present study investigated the effect of endogenous BDNF on the biological behavior of cervix cancer cells using small interfering RNA (siRNA). HeLa, a cervix cancer cell line with high expression of BDNF, was used as a living model to screen out the effective s...
Source: Oncology Reports - April 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma.
Authors: Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z, Liu Y Abstract Previous studies indicated that phosphoglycerate mutase 1 (PGAM1) is involved in many cancer types and promotes breast cancer progression. However, the role of PGAM1 in glioma remains unclear. The present study aimed to investigate the association of PGAM1 expression with glioma grade and the role of PGAM1 in proliferation, apoptosis, migration and invasion of glioma cells. The mRNA and protein expression of PGAM1 was analysed in glioma tissues and normal brain tissues. The expression of PGAM1 was examined further by immunohistochemical anal...
Source: Oncology Reports - September 1, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma.
In conclusion, silencing of ATM via the siRNA technique could improve the in vitro and in vivo radiosensitivity of glioma cells. PMID: 27108486 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 27, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway.
In conclusion, SEPT7 is involved in glioma cell migration with the assistance of cofilin phospho‑mediated cytoskeleton locomotion. PMID: 26846171 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 9, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of cortactin in human gliomas and its effect on migration and invasion of glioma cells.
Authors: Wang L, Zhao K, Ren B, Zhu M, Zhang C, Zhao P, Zhou H, Chen L, Yu S, Yang X Abstract The aim of the present study was to investigate the role of cortactin in the infiltrative behavior of glioma cells and the potential mechanism of cortactin in promoting the migration and invasion of glioma cells. The expression of cortactin was detected by immunohistochemistry in 40 human glioma specimens and 8 non-tumor brain specimens. U251, LN229 and SNB19 glioma cells were employed for the in vitro study and assigned into the siRNA-cortactin (transfected with siRNA specific to cortactin), siRNA-NC (transfected with ...
Source: Oncology Reports - August 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research