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DKK1 Affects Survival of Patients with Head and Neck Squamous Cell Carcinoma by Inducing Resistance to Radiotherapy and Immunotherapy
CONCLUSION: Our data show that DKK1 can affect both radiotherapy and immunotherapy in HNSC, suggesting that DKK1 can be a potential target for radioimmunology in HNSC.PMID:36690301 | DOI:10.1016/j.radonc.2023.109485
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2023 Category: Radiology Authors: Xinyu Ye Jingwen Liu Rencui Quan Yi Lu Jian Zhang Source Type: research

Growth inhibition and chemo-radiosensitization of head and neck squamous cell carcinoma (HNSCC) by survivin-siRNA lentivirus
In this study, we investigated the effect of survivin knockdown by survivin-siRNA lentiviral vector (Svv-Lent) on the response of HNSCC to chemo-radiotherapy, tumor growth and metastasis.
Source: Radiotherapy and Oncology - December 30, 2015 Category: Radiology Authors: Zakir Khan, Abdul Arif Khan, Godavarthi B.K.S. Prasad, Noor Khan, Ram Pramod Tiwari, Prakash Singh Bisen Tags: Original article Source Type: research

AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
CONCLUSION: Under clinically relevant hypoxia (1% O2) the stimulation of autophagy mediates resistance of hypoxic tumor cells to ionizing radiation, which is independent of AMPK signaling. PMID: 26318663 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 26, 2015 Category: Radiology Authors: Chaachouay H, Fehrenbacher B, Toulany M, Schaller M, Multhoff G, Rodemann HP Tags: Radiother Oncol Source Type: research

Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells
Conclusion: Targeting Ras and PI3K activity improves the outcome of irradiation in cetuximab-resistant HNSCC cell lines in vitro.
Source: Radiotherapy and Oncology - July 29, 2013 Category: Radiology Authors: Mohammad Saki, Mahmoud Toulany, H. Peter Rodemann Tags: Original Articles Source Type: research