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801 Novel nanoparticles mediate efficient siRNA/mRNA co-delivery to melanoma
Checkpoint immunotherapy has revolutionized treatment for patients with advanced or metastatic melanoma; however, many patients ’ tumors either fail to respond or develop secondary resistance. As a result, there is an urgent need for an off-the-shelf local treatment that can improve therapeutic outcomes by increasing immune activation and reducing immunosuppressive factors. We developed a library of novel lipophilic poly(b eta-amino ester) (PBAE)-based biodegradable nanoparticle (NP) formulations with different backbone, sidechain, and endcap monomers and various lipophilic/linear ratios to efficiently co-deliver mRNA an...
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: K.M. Luly, E.E. Rocher, J.J. Green, S.Y. Tzeng, J.C. Sunshine Source Type: research

1249 Research of hiperfect-mediated RNA interference targeting hTERT on the biological behavior of the human malignant melanoma cell line A375
Objective: To Research of hiperfect-mediated RNA interference targeting human telomerase reverse transcriptase gene (hTERT) on the biological behavior of the human malignant melanoma cell line A375.Methods: Specific siRNAs with green fluorescent labeling on different concentrations were transfected into A375 cells by using transfection reagent (Hiperfect) at different volumes . The transfection efficiency of cells was determined by fluorescen microscop, and the concentration of siRNA and volume of Hipetfect were selected.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: J. Zhao, Z. Mosha, X. Kang Source Type: research

652 EPAC-mTORC1 signaling regulates proliferation of primary melanoma cells and loss of dependence on EPAC signaling correlates with melanoma progression
In this study, we show that pharmacological inhibition or siRNA-mediated knockdown of EPAC selectively inhibits the growth and survival of primary melanoma cells by downregulation of cell cycle proteins and inhibiting the cell cycle progression independent of ERK1/2 phosphorylation.
Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: M.K. Singh, A. Krishnan, A.I. Bhasker, C.I. Rodriguez, E. Castro-Perez, M. Ndiaye, N. Ahmad, H. Khan, S.M. Schieke, V. Setaluri Source Type: research

Correction to: Thick melanoma in Tuscany
G Ital Dermatol Venereol. 2020 Dec;155(6):807. doi: 10.23736/S0392-0488.21.06995-9.ABSTRACTThis corrects the article DOI: 10.23736/S0392-0488.17.05584-5.PMID:33645939 | DOI:10.23736/S0392-0488.21.06995-9
Source: Giornale Italiano di Dermatologia e Venereologia - March 1, 2021 Category: Dermatology Authors: Alessandra Chiarugi Paolo Nardini Lorenzo Borgognoni Paola Brandani Gianni Gerlini Pietro Rubegni Arianna Lamberti Camilla Salvini Giovanni Lo Scocco Roberto Cecchi Riccardo Sirna Stefano Lorenzi Riccardo Gattai Silvio Battistini Emanuele Crocetti Source Type: research

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