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Cancers, Vol. 14, Pages 5621: Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
. Bhat Shahab Uddin Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for MM, the disease remains incurable for most patients owing to emergence of drug-resistant cancerous cells. Guggulsterone (GS), a phytosteroid, extracted from the gum resin of guggul plant, has displayed various anticancer activities in vitro and in vivo; however, the molecular mechanisms of its anticancer activity have not been evaluated in MM cells. Therefore, in this study, we i...
Source: Cancers - November 16, 2022 Category: Cancer & Oncology Authors: Sabah Akhtar Lubna Zarif Shilpa Kuttikrishnan Kirti S. Prabhu Kalyani Patil Sabah Nisar Haissam Abou-Saleh Maysaloun Merhi Said Dermime Ajaz A. Bhat Shahab Uddin Tags: Article Source Type: research

Cancers, Vol. 14, Pages 1592: Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma
Conclusion: Our findings provide a rationale for the therapeutic targeting of MDM2/c-Myc axis to improve clinical outcome of patients with refractory/relapsed MM.
Source: Cancers - March 21, 2022 Category: Cancer & Oncology Authors: Omar Faruq Davidson Zhao Mariusz Shrestha Andrea Vecchione Eldad Zacksenhaus Hong Chang Tags: Article Source Type: research

Cancers, Vol. 14, Pages 566: Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts
In conclusion, exosome-capturing Ab-conjugated siRNAs with branched Arg linkers can be effectively delivered into MM cells via uptake of exosomes by parental cells. This technology has the potential to lead to a breakthrough in drug delivery systems for hematologic cancers.
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Emi Soma Asako Yamayoshi Yuki Toda Yuji Mishima Shigekuni Hosogi Eishi Ashihara Tags: Article Source Type: research

Cancers, Vol. 12, Pages 2952: A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma
S. Schneekloth Mock New approaches to target MYC include the stabilization of a guanine-rich, G-quadruplex (G4) tertiary DNA structure in the NHE III region of its promoter. Recent screening of a small molecule microarray platform identified a benzofuran, D089, that can stabilize the MYC G4 and inhibit its transcription. D089 induced both dose- and time-dependent multiple myeloma cell death mediated by endoplasmic reticulum induced stress. Unexpectedly, we uncovered two mechanisms of cell death: cellular senescence, as evidenced by increased levels of p16, p21 and γ-H2AX proteins and a caspase 3-indep...
Source: Cancers - October 13, 2020 Category: Cancer & Oncology Authors: Snehal M. Gaikwad Zaw Phyo Anaisa Quintanilla Arteaga Sayeh Gorjifard David R. Calabrese Daniel Connors Jing Huang Aleksandra M. Michalowski Shuling Zhang Zheng-Gang Liu John S. Schneekloth Mock Tags: Article Source Type: research