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Inhibition of VCP modulates NF- κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
This study aims to identify if VCP is a therapeutic target in MM and confirm the effect of a novel inhibitor of VCP (VCP20) on MM. We found that VCP was elevated in MM patients and correlated with shorter survival in clinical TT2 cohort. Silencing VCP using siRNA resulted in decreased MM cell proliferation via NF-κB signaling pathway. VCP20 evidently inhibited MM cell proliferation and osteoclast differentiation. Moreover, exosomes containing VCP derived from MM cells partially alleviated the inhibitory effect of VCP20 on cell proliferation and osteoclast differentiation. Mechanism study revealed that VCP20 inactivated th...
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Rongfang Wei Yuhao Cao Hongjie Wu Xin Liu Mingmei Jiang Xian Luo Zhendong Deng Ze Wang Mengying Ke Yongqiang Zhu Siqing Chen Chunyan Gu Ye Yang Source Type: research

DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway
In conclusion, we establish DAZAP1 as a tumor-promoting gene with therapeutic potential and provide mechanistic insights into targeting DAZAP1 as a new strategy for the diagnosis and treatment of MM.PMID:36242590 | DOI:10.18632/aging.204326
Source: Aging - October 15, 2022 Category: Biomedical Science Authors: Yanyan Zhou Shaohua Huangfu Muxi Li Chao Tang Jinjun Qian Mengjie Guo Zuojian Zhou Ye Yang Chunyan Gu Source Type: research

Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis.
Abstract Chemoresistance is still a critical challenge for efficient treatment of multiple myeloma (MM) during the bortezomib-based chemotherapy. Recent studies have suggested that heme oxygenase-1 (HO-1) is involved in apoptosis, proliferation and chemoresistance in cancer cells. Here we aim to investigate the role and mechanism of HO-1 in bortezomib-sensitivity to myeloma cells. In the study population, we found that HO-1 was highly expressed in CD138+ primary myeloma cells, which was positively associated with Gas6 expression and Gas6 plasma levels in MM patients. Downregulation of HO-1 using pharmacological in...
Source: Aging - April 15, 2020 Category: Biomedical Science Authors: Zhang Z, Wang W, Ma D, Xiong J, Kuang X, Zhang S, Fang Q, Wang J Tags: Aging (Albany NY) Source Type: research