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Dysregulation of the TOX-RUNX3 pathway in cutaneous T-cell lymphoma.
Authors: Dulmage BO, Akilov O, Vu JR, Falo LD, Geskin LJ Abstract Studies have examined gene expression changes in Sézary syndrome (SS), but disease pathogenesis remains largely unknown, and diagnosis and treatment are difficult. TOX is a transcription factor involved in CD4+ T-cell development with downstream effects on RUNX3, a known tumor suppressor gene. We sought to identify genes involved in SS disease pathogenesis with the potential to enable diagnosis and treatment. We utilized previously reported transcriptome sequencing data to construct a list of candidate genes, which was narrowed using pathway analysi...
Source: Oncotarget - May 30, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.
In conclusion, we provide the first evidence for an ectopic expression of CD22 and a novel splice variant regulating malignant proliferation and survival in CTCL. Analysis of expression and function of CD22 in cutaneous lymphomas may form the basis for development of novel targeted therapies for our patients. PMID: 25957418 [PubMed - as supplied by publisher]
Source: Oncotarget - May 11, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research