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Chinese giant salamander Bcl-w: An inhibitory role in iridovirus-induced mitochondrial apoptosis and virus replication
In this study, we characterized for the first time an amphibian Bcl-w from Chinese giant salamander Andrias davidianus (AdBcl-w), and its function and regulatory mechanism during GSIV infection were investigated. AdBcl-w possesses the conserved structural features of Bcl-w and shares 35-54% sequence identities with other Bcl-w. mRNA expression of AdBcl-w was most abundant in liver and muscle. The AdBcl-w mRNA expression was regulated during GSIV infection. Western blotting assays revealed that the level of Bcl-w protein was downregulated markedly as the infection progresses. Confocal microscopy showed that overexpressed Ad...
Source: Virus Research - August 19, 2023 Category: Virology Authors: Yiqun Li Mingyang Xue Yanlin Dai Yixing Xie Ying Wei Cheng Wang Mingzhu Tian Yuding Fan Nan Jiang Chen Xu Wenzhi Liu Yan Meng Yong Zhou Source Type: research

Chinese Giant Salamander Bcl-w:An Inhibitory Role in Iridovirus-Induced Mitochondrial Apoptosis and Virus Replication
In this study, we characterized for the first time an amphibian Bcl-w from Chinese giant salamander Andrias davidianus (AdBcl-w), and its function and regulatory mechanism during GSIV infection were investigated. AdBcl-w possesses the conserved structural features of Bcl-w and shares 35% - 54% sequence identities with other Bcl-w. mRNA expression of AdBcl-w was most abundant in liver and muscle. The AdBcl-w mRNA expression was regulated during GSIV infection. Western blotting assays revealed that the level of Bcl-w protein was downregulated markedly as the infection progresses. Confocal microscopy showed that overexpressed...
Source: Virus Research - August 19, 2023 Category: Virology Authors: Yiqun Li Mingyang Xue Yanlin Dai Yixing Xie Ying Wei Cheng Wang Mingzhu Tian Yuding Fan Nan Jiang Chen Xu Wenzhi Liu Yan Meng Yong Zhou Source Type: research

Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research

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