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Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway.
In this study, tumor-bearing mice were used as the animal model and Hela cells were used as cellular model. In vivo experiments have showed that OA significantly reduced the size and mass of cervical cancer tumors in mice. In vitro experiments have showed that OA significantly reduced the viability and proliferative capacity of Hela cells. In both in vivo and in vitro assays, OA increased the oxidative stress levels and Fe2+ content, and increased the expression of ferroptosis-related proteins. We found that ACSL4 was highly expressed in both xenograft models and cervical carcinoma cells with OA treatment. Further use o...
Source: Biochemical and Biophysical Research communications - February 2, 2021 Category: Biochemistry Authors: Xiaofei J, Mingqing S, Miao S, Yizhen Y, Shuang Z, Qinhua X, Kai Z Tags: Biochem Biophys Res Commun Source Type: research