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Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells
Abstract Hexokinase II (HK2), the enzyme that catalyzes the first committed step of glycolysis, is overexpressed in many cancers, as is the central signaling kinase Akt. Akt activity promotes HK2 association with the mitochondria, as well as glucose uptake by cancer cells. In HeLa cervical cancer cells, Akt inhibitor IV (Ai4) increased nuclear HK2 localization, while in MDA‐MB‐231 breast cancer cells, Ai4 merely induced cytoplasmic redistribution without increased nuclear accumulation. Small interfering RNA (siRNA) directed against Akt confirmed the effect in HeLa cells. Next, we treated the cells with clotrimazole (CT...
Source: Journal of Cellular Physiology - April 30, 2013 Category: Cytology Authors: Catherine L. Neary, John G. Pastorino Tags: Original Research Article Source Type: research