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Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma
Biomed Pharmacother. 2022 Mar 31;149:112888. doi: 10.1016/j.biopha.2022.112888. Online ahead of print.ABSTRACTSynovial sarcoma is typical aggressive malignant without satisfactory treatment outcome in adult series. Cyclin-dependent kinases (CDKs) in transcription have been considered promising molecular targets in cancer. Among these, CDK7 has been shown to play important roles in the pathogenesis of malignancies. However, the modulation mechanism of CDK7-regulated transcription in synovial sarcoma is unknown. In the present study, we aim to determine the expression and function of CDK7 in the transcription cycle of RNA po...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2022 Category: Drugs & Pharmacology Authors: Xiaoyang Li Dylan C Dean Jin Yuan Thomas H Temple Jonathan C Trent Andrew E Rosenberg Shengji Yu Francis J Hornicek Zhenfeng Duan Source Type: research