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Furowanin A Exhibits Anti-proliferative and Pro-apoptotic Activities by Targeting Sphingosine Kinase 1 in Osteosarcoma.
This study is designed to evaluate the efficacy of Fur A against OS. The effect of Fur A on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. Western blotting and quantitative real-time PCR (qRT-PCR) were performed to determine the protein and mRNA level of sphingosine kinase 1 (SphK1), respectively. To validate the role of SphK1 in the pro-apoptotic activity of Fur A, overexpressing SphK1 vector and siRNA targeting SphK1 were utilized to transfect OS cells. Moreover, a OS xenograft murine model was used to analyze the therapeutic efficacy of Fur A in vivo. Fur A treatment led to a dose-dependent decrease i...
Source: Anatomical Record - June 13, 2019 Category: Anatomy Authors: Wei K, Sun H, Chen X, Chen Q, Li Y, Wu H Tags: Anat Rec (Hoboken) Source Type: research