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Identification of DJ ‐1 as a contributor to multidrug resistance in human small‐cell lung cancer using proteomic analysis
Summary Proteomic approaches have been proven to provide an important tool in identifying drug resistance‐associated proteins. The aim of this study was to investigate the protein profiling of drug resistance‐related proteins in small‐cell lung cancer (SCLC) by proteomic analysis. The proteomic profiling was performed by two‐dimensional fluorescence difference gel electrophoresis (2D‐DIGE) coupled with MALDI‐TOF‐TOF of SCLC in the multidrug‐resistant cell line H69AR and its parental cell line H69. A total of 11 proteins were identified to be >2‐fold up‐or downregulated between the two cell lines. DJ�...
Source: International Journal of Experimental Pathology - June 5, 2017 Category: Pathology Authors: Hongyi Gao, Yuchun Niu, Man Li, Shun Fang, Linlang Guo Tags: Original Article Source Type: research

Role of homeobox gene A5 in multidrug resistance of human small cell lung cancer cells.
CONCLUSION: HOXA5 may play an important role in multidrug resistance of SCLC and can be a potential therapeutic target in clinical treatment of SCLC. PMID: 24273274 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2013 Category: Universities & Medical Training Authors: Xiao FM, Chen ZZ, Zeng XP, Bai YF, Guo LL, Li YF Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research