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Cancers, Vol. 11, Pages 1848: The Potential Impact of Connexin 43 Expression on Bcl-2 Protein Level and Taxane Sensitivity in Head and Neck Cancers –In Vitro Studies
This study aimed to test the role of Cx43 protein on Bcl-2 expression, tumor progression and response to taxane-based treatment in HNSCC. Human papillomavirus (HPV) negative HNSCC cell lines were tested for paclitaxel sensitivity through measuring apoptosis induction, cell viability and changes in Cx43 and Bcl-2 levels using flow cytometry, cell viability assay, immunocytochemistry and western blot. Inhibition of Cx43 expression using siRNA increased Bcl-2 protein levels in SCC25 (tongue squamous cell carcinoma) cells, while forced Cx43 expression reduced Bcl-2 levels and supported paclitaxel cytotoxicity in FaDu (hypophar...
Source: Cancers - November 21, 2019 Category: Cancer & Oncology Authors: Bianka Gurbi Di ána Brauswetter Attila Varga P ál Gyulavári Kinga P énzes J ózsef Murányi Veronika Z ámbó Ede Birtalan Tibor Kren ács David Laurence Becker Mikl ós Csala Istv án Vályi-Nagy Istv án Peták Korn él Dános Tags: Article Source Type: research