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Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone.
Abstract Ewing sarcoma is a malignant bone cancer that primarily occurs in children and adolescents. Eighty-five percent of Ewing sarcoma is characterized by the presence of the aberrant chimeric EWS/FLI1 fusion gene. Previously, we demonstrated that an interaction between EWS/FLI1 and wild-type EWS led to the inhibition of EWS activity and mitotic dysfunction. Although defective mitosis is considered to be a critical step in cancer initiation, it is unknown how interference with EWS contributes to Ewing sarcoma formation. Here, we demonstrate that the EWS/FLI1- and EWS-knockdown cells display a high incidence of ...
Source: Cell Cycle - June 19, 2014 Category: Cytology Authors: Park H, Turkalo TK, Nelson K, Folmsbee SS, Robb C, Belford B, Azuma M Tags: Cell Cycle Source Type: research