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Activation of TGF- β - SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK
In this study, PCa cells were differentiated with IL-6 in in-vitro to identify novel targets or signaling pathways associated with emergence of NEPC on deprivation of androgens. From the results, we observed an activation of TGF-β signaling pathway is altered through multiple proteins in differentiated LNCaP cells. Hence, we investigated the role of TGF-β axis in PCa cells differentiation. LNCaP cells treated with IL-6 in androgens deprived media release excess TGF-β ligand and this as conditioned media added to cells stimulated NED of PCa cells. TGF-β released by IL-6 stimulated cells activate p38MAPK through SMAD2 th...
Source: Cellular Signalling - January 5, 2022 Category: Cytology Authors: Sirisha Natani K K Sruthi Sakkarai Mohamed Asha Priyanka Khilar Pampana Sandhya Venkata Lakshmi Ramesh Ummanni Source Type: research

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.
Abstract While androgen deprivation therapy (ADT) reduces tumor burden, autocrine growth factor loops such as human epidermal growth factor receptor 2 (HER2/ErbB-2/neu) have been proposed to contribute to prostate cancer (PCa) survival and relapse. However, the role of ErbB-2 in regulating androgen-sensitive (AS) and castration-resistant (CR) cell proliferation remains unclear. Here, we determined the role of ErbB-2 in PCa progression and survival under steroid-reduced conditions using two independent PCa cell progression models. In AR-positive androgen-independent (AI) PCa cells that exhibit the CR phenotype, Erb...
Source: Cellular Signalling - August 6, 2015 Category: Cytology Authors: Muniyan S, Chen SJ, Lin FF, Wang Z, Mehta PP, Batra SK, Lin MF Tags: Cell Signal Source Type: research