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SiRNA knockdown of the DEK nuclear protein mRNA enhances apoptosis and chemosensitivity of canine transitional cell carcinoma cells
Publication date: Available online 12 February 2015 Source:The Veterinary Journal Author(s): Hiroki Yamazaki , Tomomi Iwano , Saori Otsuka , Yumiko Kagawa , Yuki Hoshino , Kenji Hosoya , Masahiro Okumura , Satoshi Takagi Transitional cell carcinoma (TCC) in dogs is an aggressive malignant neoplasm originating in the epithelium of the urinary bladder. The DEK nuclear protein is overexpressed in several types of human bladder cancer, where it is involved in chromatin reconstruction, gene transcription and apoptosis. Since DEK represents a potential therapeutic target for canine TCC, this study was designed to investigate D...
Source: The Veterinary Journal - February 13, 2015 Category: Veterinary Research Source Type: research