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Specialty: Cytology
Cancer: Clear Cell Carcinoma
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Total 1 results found since Jan 2013.
Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation
J Pineal Res. 2021 Nov 26:e12781. doi: 10.1111/jpi.12781. Online ahead of print.ABSTRACTMelatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic roles in cancer cells. Previously, we showed that melatonin induced the expression of Bim, a pro-apoptotic Bcl-2 protein, at both the transcriptional and post-translational levels. In the present study, we investigated the molecular mechanisms underlying the melatonin-mediated Bim upregulation through post-translational regulation. We found that ovarian tumor domain-containing protein 1 (OTUD1), a deubiquitinase belonging to the OTU pro...
Source: Cell Research - November 26, 2021 Category: Cytology Authors: Seon Min Woo Seung Un Seo Kyoung-Jin Min Taeg Kyu Kwon Source Type: research
