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What to use instead of NICE Evidence Search - a first thought
I have been promoting NICE Evidence Search much more systematically this year to " my " first year undergraduates in their first library session.  It is also on the resource lists I ' ve made for each of their courses.  I like the idea that there is one source, where all the results have been evaluated by health information professionals, and I ' ve suggested it ' s a good first place to search for any health topic.  But NICE Evidence Search is closing at the end of March 2022.  So what to use instead?NICE Evidence Search has two lists of sources, one of sites where some of the content is...
Source: Browsing - February 9, 2022 Category: Databases & Libraries Tags: NICE Evidence Search Source Type: blogs

Visual search in breast imaging: A review.
Abstract Breast cancer is the most common cancer among females worldwide and large volumes of breast images are produced and interpreted annually. As long as radiologists interpret these images, the diagnostic accuracy will be limited by human factors and both false-positive and false-negative errors might occur. By understanding visual search in breast images, we may be able to identify causes of diagnostic errors, find ways to reduce them, and also provide a better education to radiology residents. Many visual search studies in breast radiology have been devoted to mammography. These studies showed that 70% of m...
Source: The British Journal of Radiology - July 8, 2019 Category: Radiology Authors: Gandomkar Z, Mello-Thoms C Tags: Br J Radiol Source Type: research

Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation
Conclusions: This study demonstrated that NAR targeted microglial NLRP3 inflammasome to protect DA neurons against LPS-induced neurotoxicity. These findings suggest NAR might hold a promising therapeutic potential for PD. Background Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. It is characterized by slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN) with the accumulation of α-synuclein in Lewy bodies and neuritis (1). Although the etiology of PD remains unclear, amounts of studies have suggested that ne...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

The NICE OECD countries' geographic search filters: Part 1-methodology for developing the draft MEDLINE and Embase (Ovid) filters
CONCLUSION: The draft filters look promising-they reduced search result volumes while retaining most OECD country evidence from MEDLINE and Embase. However, we advise caution when using them in topics about both non-OECD and OECD countries. We have created final versions of the search filters and will validate them in a future study.PMID:34285668 | PMC:PMC8270368 | DOI:10.5195/jmla.2021.978
Source: J Med Libr Assoc AND... - July 21, 2021 Category: Databases & Libraries Authors: Lynda Ayiku Paul Levay Thomas Hudson Source Type: research