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18FFDG PET/CT for predicting triple-negative breast cancer outcomes after neoadjuvant chemotherapy with or without pembrolizumab
CONCLUSION: High tumor metabolism (SUVmax) and low tumor burden (TMTV) could predict pCR after NAC regardless of the addition of pembrolizumab. Further studies are warranted to validate such findings and determine how these biomarkers could be used to guide neoadjuvant therapy in TNBC patients.PMID:37606858 | DOI:10.1007/s00259-023-06394-y
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Romain-David Seban Emilie Arnaud Delphine Loirat Luc Cabel Paul Cottu Lounes Djerroudi Segolene Hescot Pierre Loap Claire Bonneau Francois-Clement Bidard Virginie Huchet Nina Jehanno Arnaud Berenbaum Laurence Champion Irene Buvat Source Type: research

Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer
Chem Biol Interact. 2023 Jul 5:110605. doi: 10.1016/j.cbi.2023.110605. Online ahead of print.ABSTRACTIn spite of unprecedented advances in modern cancer therapy, there is still a dearth of targeted therapy to circumvent Triple-negative breast cancer (TNBC). Paclitaxel is the front-line therapy against TNBC, but the main constraints of its treatment are dose-related adverse effects and emerging chemoresistance. In this context, glabridin (phytoconstituent from Glycyrrhiza glabra) is reported to hit multiple signalling pathways at the in-vitro level, but hardly any information is known at the in-vivo level. We aimed here to ...
Source: Chemico-Biological Interactions - July 7, 2023 Category: Molecular Biology Authors: Ashiya Jamwal Jagdish Chand Anshurekha Dash Shipra Bhatt Sumit Dhiman Priya Wazir Buddh Singh Anindya Goswami Utpal Nandi Source Type: research

Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition
Chem Biol Interact. 2023 Jun 6:110546. doi: 10.1016/j.cbi.2023.110546. Online ahead of print.ABSTRACTCuproplasia, or copper-dependent cell proliferation, has been observed in varieties of solid tumors along with aberrant copper homeostasis. Several studies reported good response of patients to copper chelator assisted neoadjuvant chemotherapy, however, the internal target molecules are still undetermined. Unravel copper-associated tumor signaling would be valuable to forge new links to translate biology of copper into clinical cancer therapies. We evaluated the significance of high-affinity copper transporter-1 (CTR1) by b...
Source: Chemico-Biological Interactions - June 8, 2023 Category: Molecular Biology Authors: Ruiman Geng Nengwen Ke Ziyao Wang Yu Mou Bin Xiang Zhengkun Zhang Xuxu Ji Jiaqiong Zou Dingxue Wang Zhaoru Yin Xubao Liu Fang Xie Yanan Zhao Dan Chen Jingying Dong Wenbing Wu Lihong Chen Huawei Cai Ji Liu Source Type: research

Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review
Curr Issues Mol Biol. 2023 May 22;45(5):4495-4517. doi: 10.3390/cimb45050285.ABSTRACTIt is well-established that tumor antigens and molecules expressed and secreted by cancer cells trigger innate and adaptive immune responses. These two types of anti-tumor immunity lead to the infiltration of the tumor's microenvironment by immune cells with either regulatory or cytotoxic properties. Whether this response is associated with tumor eradication after radiotherapy and chemotherapy or regrowth has been a matter of extensive research through the years, mainly focusing on tumor-infiltrating lymphocytes and monocytes and their sub...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Ioannis M Koukourakis Kalliopi Platoni Dina Tiniakos Vassilis Kouloulias Anna Zygogianni Source Type: research

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