Filtered By:
Specialty: Genetics & Stem Cells
Therapy: Chemotherapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 329 results found since Jan 2013.
Genes, Vol. 14, Pages 1807: Aldehyde Dehydrogenase Genes as Prospective Actionable Targets in Acute Myeloid Leukemia
In conclusion, we identify ALDH1A1 and ALDH2 as prospective actionable targets for the treatment of AML in high-risk patients. Substances that inhibit both enzymatic activities constitute potentially effective pharmaceutics.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Garrett M. Dancik Lokman Varisli Veysel Tolan Spiros Vlahopoulos Tags: Article Source Type: research
Modern therapies of nonsmall cell lung cancer
J Appl Genet. 2023 Sep 12. doi: 10.1007/s13353-023-00786-4. Online ahead of print.ABSTRACTLung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender, with the highest mortality rates in oncology. Over the years, treatment for NSCLC has evolved from conventional surgery, chemotherapy, and radiotherapy to more tailored and minimally invasive approaches. The use of personalised therapies has increased the expected efficacy of treatment while simultaneously reducing the frequency of severe adverse effects (AEs). In this review, we discuss es...
Source: J Appl Genet - September 12, 2023 Category: Genetics & Stem Cells Authors: Andrzej Jachowski Miko łaj Marcinkowski Jakub Szyd łowski Oskar Grabarczyk Zuzanna Nogaj Łaz Marcin Andrzej P ławski Pawe ł Piotr Jagodziński Bartosz Kazimierz S łowikowski Source Type: research
Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs
This study aims to identify potential biomarkers using the latest reported gene expression signatures of oncogene-induced replication stress (ORS) in aggressive cancers, and potential anti-osteosarcoma drugs were screened in different drug databases. In this study, we obtained 89 osteosarcoma-related samples in the TARGET database, all of which included survival information. According to the median expression of each of six reported ORS gene markers (NAT10/DDX27/ZNF48/C8ORF33/MOCS3/MPP6), we divided 89 osteosarcoma gene expression datasets into a high expression group and a low expression group and then performed a differe...
Source: Biochemical Genetics - September 6, 2023 Category: Genetics & Stem Cells Authors: Meng Gao Weibo Liu Teng Li ZeLong Song XiangYu Wang XueSong Zhang Source Type: research
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
A Review of the Potential Role of CoQ10 in the Treatment of Hepatocellular Carcinoma
This article examines the effects of CoQ10 in hepatocellular carcinoma.PMID:37632587 | DOI:10.1007/s10528-023-10490-x
Source: Biochemical Genetics - August 26, 2023 Category: Genetics & Stem Cells Authors: Mahsa Liaghat Mohammad Yaghoubzad-Maleki Mohsen Nabi-Afjadi Zeinab Fathi Hamidreza Zalpoor Nafiseh Heidari Elham Bahreini Source Type: research
CircSOD2 polarizes macrophages towards the M1 phenotype to alleviate cisplatin resistance in gastric cancer cells by targeting the miR-1296/STAT1 axis
Gene. 2023 Aug 23:147733. doi: 10.1016/j.gene.2023.147733. Online ahead of print.ABSTRACTCisplatin is the first-line drug for gastric cancer (GC1). Cisplatin resistance is the most important cause of poor prognosis for GC. Increasing evidence has identified the important role of macrophage polarization in chemoresistance. CircRNAs are newly discovered non-coding RNAs, characterized by covalently closed loops with high stability. Previous studies have reported a significant difference between circRNA profiles expressed in classically activated M1 macrophages, and those expressed in alternatively activated M2 macrophages. Ho...
Source: Gene - August 25, 2023 Category: Genetics & Stem Cells Authors: Bing Qu Jiasheng Liu Zhiyang Peng Zhe Xiao Shijun Li Jianguo Wu Shengbo Li Jianfei Luo Source Type: research
Screening Single Nucleotide Polymorphisms Predicting the Efficacy of Electroacupuncture for Fatigue Treatment in Patients with Breast Cancer Following Adjuvant Chemotherapy
Biochem Genet. 2023 Aug 18. doi: 10.1007/s10528-023-10477-8. Online ahead of print.ABSTRACTChemotherapy-induced fatigue reduces not only the quality of life of patients but also effect their recurrence-free survival rate. Although electroacupuncture can relieve fatigue, it has limited affect on some patients. Therefore, appropriate biomarkers are needed to help screen patients who can benefit from electroacupuncture treatment of fatigue. We conducted this study to explore the predictive ability of SNPs on the efficacy of electroacupuncture in the treatment of fatigue in patients with breast cancer after adjuvant chemothera...
Source: Biochemical Genetics - August 18, 2023 Category: Genetics & Stem Cells Authors: Fuxing Zhao Guoshuang Shen Dengfeng Ren Miaozhou Wang Zhen Liu Yi Zhao Qiqi Xie Zhilin Liu Zitao Li Lihong Gao Jiuda Zhao Source Type: research
