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Specialty: Infectious Diseases
Vaccination: Vaccines
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Total 239 results found since Jan 2013.
Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial
This study provides insights into the design of future CMV vaccine efficacy trials, particularly for the identification of CMV infection using molecular assays.FUNDING: Merck Sharp & Dohme, a subsidiary of Merck & Co, Rahway, NJ, USA (MSD).PMID:37660711 | DOI:10.1016/S1473-3099(23)00343-2
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Rituparna Das Daniel Bl ázquez-Gamero David I Bernstein Soren Gantt Oliver Bautista Karen Beck Anthony Conlon Daniel I S Rosenbloom Dai Wang Michael Ritter Beth Arnold Paula Annunziato Kevin L Russell V160-002 study group Source Type: research
Gastrointestinal tract and viral pathogens
World J Virol. 2023 Jun 25;12(3):136-150. doi: 10.5501/wjv.v12.i3.136.ABSTRACTViral gastroenteritis is the most common viral illness that affects the gastrointestinal (GI) tract, causing inflammation and irritation of the lining of the stomach and intestines. Common signs and symptoms associated with this condition include abdominal pain, diarrhea, and dehydration. The infections commonly involved in viral gastroenteritis are rotavirus, norovirus, and adenovirus, which spread through the fecal-oral and contact routes and cause non-bloody diarrhea. These infections can affect both immunocompetent and immunocompromised indiv...
Source: Herpes - July 3, 2023 Category: Infectious Diseases Authors: Gowthami Sai Kogilathota Jagirdhar Yashwitha Sai Pulakurthi Himaja Dutt Chigurupati Salim Surani Source Type: research
Post-Marketing Safety Surveillance of Quadrivalent Influenza Vaccine (VaxigripTetra) in Children Aged 6 to 35 Months in South Korea
ConclusionThis active safety surveillance study confirms that QIV is well tolerated in children aged 6 –35 months in routine clinical practice in South Korea. There were no safety concerns observed in these young children.
Source: Infectious Diseases and Therapy - June 10, 2023 Category: Infectious Diseases Source Type: research
Top 100 Most-Cited Papers in Herpes Zoster from 2000 to 2022: A Bibliometric Study
CONCLUSION: In terms of the quantity of T100 articles, researchers, and organizations, the US is the predominant country. The most T100 papers were published in the special journal Clinical Infectious Diseases. The most academic focus remain the remedies for postherpetic neuralgia and vaccine development for individualized groups.PMID:37273270 | PMC:PMC10237222 | DOI:10.2147/JPR.S409616
Source: Herpes - June 5, 2023 Category: Infectious Diseases Authors: Ning Gao Meng Li Weiming Wang Lei Wang Zhen Liu Yufeng Guo Source Type: research
A case with prolonged headache after COVID-19 vaccination and later developed Bell's palsy
CONCLUSION: Reactivation of latent herpes virus has been suggested as one of the possible mechanisms underlying the phenomenon, but the causal pathophysiology related to the symptom needs further validation. Moreover, in the event of facial palsy post-vaccination, alternative diagnoses such as Guillain-Barre syndrome (GBS), Ramsey-Hunt syndrome, Lyme disease, trauma, central nervous system infection (CNS) infection, or stroke should also be considered.PMID:37198509
Source: Herpes - May 17, 2023 Category: Infectious Diseases Authors: Yi-Yang Hsiao Ling-Jun Liu Yo-Lin Lin Source Type: research
Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults
Am J Trop Med Hyg. 2023 May 9:tpmd220773. doi: 10.4269/ajtmh.22-0773. Online ahead of print.ABSTRACTThe radiation-attenuated Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either infants and children or adults < 50 years old. This trial was conducted in Equatorial Guinea and assessed the safety, tolerability, and immunogenicity of three direct venous inoculations of 1.8 × 106 or 2.7 × 106 PfSPZ, of PfSPZ Vaccine, or normal saline administered at 8-week interva...
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Said A Jongo Vicente Urbano Nsue Ndong Nchama L W Preston Church Ally Olotu Stephen R Manock Tobias Schindler Ali Mtoro Natasha Kc Orrin Devinsky Elcin Zan Ali Hamad Elizabeth Nyakarungu Maxmillian Mpina Anna Deal Jos é Raso Bijeri Martin Eka Ondo Mangue Source Type: research
Inactivated COVID-19 vaccine-related herpes zoster and post-herpetic neuralgia: Three case reports
In this report, we describe three cases of HZ, one of them with post-herpetic neuralgia (PHN) after receiving inactivated COVID-19 vaccine. The first two patients developed HZ 8 and 10 days after vaccination, respectively. When pain could not be controlled with paracetamol and non-steroidal anti-inflammatories, the patients received weak opioid codeine. In addition, the first patient received gabapentin, and the second patient was applied erector spinae plane block. The third patient was admitted 4 months after the diagnosis of HZ and considered to have PHN and pain palliation was provided with tramadol. Although the exact...
Source: Herpes - April 13, 2023 Category: Infectious Diseases Authors: Meltem Kanar Source Type: research
Detection of Sporadic Outbreaks of Rift Valley Fever in Uganda through the National Viral Hemorrhagic Fever Surveillance System, 2017-2020
We report 52 human cases of laboratory-confirmed RVF from 2017 to 2020. The case fatality rate was 42%. Among those infected, 92% were males and 90% were adults (≥ 18 years). Clinical symptoms were characterized by fever (69%), unexplained bleeding (69%), headache (51%), abdominal pain (49%), and nausea and vomiting (46%). Most of the cases (95%) originated from central and western districts that are part of the cattle corridor of Uganda, where the main risk factor was direct contact with livestock (P = 0.009). Other predictors of RVF positivity were determined to be male gender (P = 0.001) and being a butcher (P = 0.04)...
Source: Am J Trop Med Hyg - March 13, 2023 Category: Infectious Diseases Authors: Luke Nyakarahuka Shannon Whitmer John Klena Stephen Balinandi Emir Talundzic Alex Tumusiime Jackson Kyondo Sophia Mulei Ketan Patel Jimmy Baluku Gloria Akurut Diana Namanya Kilama Kamugisha Caitlin Cossaboom Amy Whitesell Carson Telford James Graziano Joe Source Type: research
