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Total 11 results found since Jan 2013.
Correspondence on 'EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups
The publication of the European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) 2017 classification criteria for adult and juvenile idiopathic inflammatory myopathy is a landmark with 186 citations as of date.1 Patients with dermatomyositis (DM) and polymyositis (PM) differ with respect to clinical features, autoantibody profile and treatment response and have been subgrouped for a long time now.2 We studied 26 consecutive adult patients over 1 year seen in a tertiary teaching hospital in south India, satisfying either the 2017 criteria or 1975 Bohan-Peter criteria for idiopathic inflammatory myositi...
Source: Annals of the Rheumatic Diseases - January 23, 2023 Category: Rheumatology Authors: Mohammad, I., Devarasetti, P. K., Rajasekhar, L. Tags: ARD Correspondence Source Type: research
Evaluation on the effect of acupuncture on patients with sepsis-induced myopathy (ACU-SIM pilot study): A single center, propensity-score stratified, assessor-blinded, prospective pragmatic controlled trial
This study will be deployed in a multi-professional critical care department at a tertiary teaching hospital in Guangzhou, China. Ninety-eight intensive care unit subjects will be recruited and assigned to either the control group or the acupuncture group. Both groups will receive basic treatment for sepsis, and the acupuncture group will additionally receive acupuncture treatment. The primary outcomes will be the rectus femoris cross-sectional area, the Medical Research Council sum-score and time-to-event (defined as all-cause mortality or unplanned readmission to the intensive care unit due to invasive ventilation). The ...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Should the Use of the Extended Myositis Antibody (EMA) Panel Be Part of the Routine Work-Up in Suspected Myositis? (P5.038)
Conclusions: This study illustrates the value of the EMA panel in defining a heterogeneous patient population into clinicoserological phenotypes, and consequently guiding investigation and treatment pathways. Furthermore, it highlights the diversity of possible presentation with subsequent need for multi-speciality involvement, and serves to heighten awareness among clinicians of the diagnostic use of extended myositis antibody testing in these cases. Referneces: 1. Hengstman GJD, Van Engelen BGM, Vree Egberts WTM, et al. Myositis specific autoantibodies: overview and recent developments. Curr Opin Rheumatol 2001 Nov;13:47...
Source: Neurology - April 3, 2016 Category: Neurology Authors: O' Connor, A., Mulhall, J., Harney, S., Ryan, J., Murphy, G., Henry, M., Annis, P., Ryan, A. Tags: Pathomechanism and Biomarkers in Muscle Diseases and Myasthenia Source Type: research
Teaching NeuroImages: Longitudinally extensive transverse myelitis in MELAS
A 16-year-old girl presented with acute-onset flaccid quadriparesis with urinary incontinence. Medical history unveiled generalized epilepsy since age 7 years and status epilepticus 3 years before. Multisystem compromise was absent. Family history was unremarkable. Two days after admission, generalized refractory status epilepticus occurred. Neuroimaging studies disclosed laminar cortical necrosis and longitudinally extensive transverse myelitis (LETM) in cervical and thoracic spinal cord levels (figure). Muscle biopsy disclosed subsarcolemmal mitochondrial proliferation and ragged-red fibers (figure). Genetic testing conf...
Source: Neurology - January 25, 2016 Category: Neurology Authors: Souza, P. V. S. d., Pinto, W. B. V. d. R., Oliveira, A. S. B. Tags: MRI, Metabolic disease (inherited), Spinal cord tumor, All Epilepsy/Seizures, Mitochondrial disorders RESIDENT AND FELLOW SECTION Source Type: research
Teaching Video NeuroImages: Feeding dystonia in chorea-acanthocytosis
A 39-year-old man was evaluated for personality change, involuntary movements, and eating difficulties. Examination demonstrated feeding dystonia, dysarthria, limb dystonia, and chorea (video on the Neurology® Web site at Neurology.org). Transaminases and creatine kinase levels were elevated. Additional investigation revealed acanthocytes on blood smear, myopathy, and caudate nucleus atrophy (figures 1, 2, e-1, and e-2). Western blot revealed absent chorein, and a genetic test found him to be compound heterozygote for novel VPS13A gene mutations (c.266dupT and deletion of exons 52, 53, 55, and 58), establishing a diagn...
Source: Neurology - November 9, 2015 Category: Neurology Authors: Paucar, M., Lindestad, P.-A., Walker, R. H., Svenningsson, P. Tags: All Movement Disorders, Botulinum toxin, Basal ganglia RESIDENT AND FELLOW SECTION Source Type: research
Twenty years later: a single‐centre, repeat retrospective analysis of equine perioperative mortality and investigation of recovery quality
Conclusion and clinical relevanceAnaesthetic/recovery‐associated mortality was comparable to previously reported figures except intra‐operative deaths were not reported. Fractures remained responsible for the largest proportion of recovery‐associated deaths. Improvements to the recovery process that can reduce fracture occurrence are still required.
Source: Veterinary Anaesthesia and Analgesia - June 17, 2015 Category: Veterinary Research Authors: Alexandra HA Dugdale, Jessica Obhrai, Peter J Cripps Tags: Research Paper Source Type: research
Teaching Video NeuroImages: Myoedema in hypothyroidism
A 22-year-old man with 2 years of malaise and diffuse muscular enlargement complained of slow movements. Clinical examination showed myxedematous facies, lentification of deep tendinous reflexes, and a mounding phenomenon (video on the Neurology® Web site at Neurology.org). Laboratory examinations revealed hypothyroidism and elevated muscular enzymes, suggesting the diagnosis of myxedematous myopathy.
Source: Neurology - January 26, 2015 Category: Neurology Authors: Capistrano, G. G., Galdino, G. S. Tags: Endocrine, Clinical neurology examination, All Movement Disorders, Muscle disease RESIDENT AND FELLOW SECTION Source Type: research
Teaching NeuroImages: Dyspnea as a presenting manifestation of amyloid myopathy
Source: Neurology - January 13, 2014 Category: Neurology Tags: CORRECTIONS Source Type: research
Teaching Video NeuroImages: Complicated scapular winging
Scapular winging (SW) is a common sign in neuromuscular disorders. Besides "pure" phenotypes due to single muscle weakness often secondary to nerve injuries or dysfunctions,1,2 the phenotype can be complicated when a combination of different scapular fixators is involved with a myopathy. We show an example of 2 sisters with facioscapulohumeral muscular dystrophy (video 1 on the Neurology® Web site at www.neurology.org). In patient 1, the SW is caused by an isolated trapezius weakness. Conversely, in patient 2, the left SW can be attributed on clinical grounds to a combined serratus anterior and trapezius weakness. Both...
Source: Neurology - September 16, 2013 Category: Neurology Authors: Monforte, M., Ricci, E., Iannaccone, E., Tasca, G. Tags: MRI, Clinical neurology examination, Muscle disease RESIDENT AND FELLOW SECTION Source Type: research
Teaching NeuroImages: Hydroxychloroquine-induced vacuolar myopathy
A 58-year-old woman with long-standing mixed connective tissue disorder had proximal leg weakness for 4 months. She had been treated with 400 mg/day of hydroxychloroquine and varying doses of prednisone over 15 years. Creatine kinase was 600 U/mL. MRI of quadriceps showed edema and its biopsy revealed myriad acid-phosphatase–positive autophagic vacuoles indicating increased lysosomal activity (figure). Hydroxychloroquine induces autophagy by reducing lysosomal acidity.1 Autophagic vacuolar myopathy can be seen with chloroquine or colchicine therapy or in inherited disorders (α-glucosidase deficiency, Danon dise...
Source: Neurology - June 3, 2013 Category: Neurology Authors: Ghosh, P. S., Swift, D., Engel, A. G. Tags: Autoimmune diseases, Muscle disease, Other toxicology RESIDENT AND FELLOW SECTION Source Type: research
