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Total 13 results found since Jan 2013.

Biomimetic hydroxyapate/polydopamine composites with good biocompatibility and efficiency for uncontrolled bleeding
AbstractUncontrolled bleeding is thought to be the most deadly cause of pre ‐hospital, traffic, and military accidents death. However, the popular commercial hemostats can only realize the hemostasis of mild bleeding. Therefore, we developed polydopamine (PDA) composite materials (PMs), which applied hydroxyapatite as the parent body. The PMs were produced via lyophilizat ion and functionalized with amino, phenol hydroxyls groups, which endowed hydrophobicity to materials. This ensured a high aggregation ability of blood cells to the PMs and they were tested to be as high as 300% compared with the negative control group....
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - April 13, 2021 Category: Materials Science Authors: Mengxiang Gong, Chenyu Liu, Chunyu Liu, Lingyi Wang, Farishta Shafiq, Xia Liu, Guozhen Sun, Qiling Song, Weihong Qiao Tags: RESEARCH ARTICLE Source Type: research

Characterization of shape memory polymer foam hemostats in in vitro hemorrhagic wound models
AbstractShape memory polymer foam hemostats are a promising option for future hemorrhage control in battlefield wounds. To enable their use as hemostatic devices, they must be optimized in terms of formulation and architecture, and their safety and efficacy must be characterized in animal models. Relevant in vitro models can be used for device optimization to help mitigate the excess use of animals and reduce costs of clinical translation. In this work, a simplified gunshot wound model and a grade V liver injury model were constructed. The models were used to characterize the effects of shape memory polymer foam hemostat g...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 4, 2021 Category: Materials Science Authors: Nakira Christmas, Anand Utpal Vakil, Christopher J. Hatch, Shi Dong, David Fikhman, Henry T. Beaman, Mary Beth B. Monroe Tags: ORIGINAL RESEARCH REPORT Source Type: research

ASAP Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing
Chemistry of MaterialsDOI: 10.1021/acs.chemmater.0c02030
Source: Chemistry of Materials - July 30, 2020 Category: Materials Science Authors: Ying Huang †?, Xin Zhao†?, Zhiyi Zhang†, Yongping Liang†, Zhanhai Yin§, Baojun Chen§, Lang Bai§, Yong Han†, and Baolin Guo*†‡ Source Type: research

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective
AbstractIn recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting ‐edge technology, including minimally invasive and organ‐preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bl eeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for eff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 25, 2020 Category: Materials Science Authors: Margarida Pacheco, Alexandre A. Barros, Ivo M. Aroso, Riccardo Autorino, Est êvão Lima, Joana M. Silva, Rui L. Reis Tags: REVIEW ARTICLE Source Type: research

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis
AbstractFibrin glue has been widely used as a surgical sealing and hemostatic agent. Its application is restricted due to poor tissue adhesion and low mechanical strength. To develop better tissue sealant and hemostatic agent, this study prepared the injectable hydrogels by chemically cross ‐linking gelatin (G) with or without hyaluronic acid (HA) in situ at a mild condition. The rheological analysis, Fourier transform infrared spectroscopy, swelling, proteolytic degradation, biocompatibility, tissue sealing, and hemostatic ability of the hydrogels were investigated. It was found tha t the chemical cross‐linking rapidl...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 20, 2019 Category: Materials Science Authors: Jing ‐Wan Luo, Chang Liu, Jing‐Heng Wu, Dan‐Hui Zhao, Long‐Xiang Lin, Hai‐Ming Fan, Yu‐Long Sun Tags: ORIGINAL RESEARCH REPORT Source Type: research

In-vitro and in-vivo evaluation of hemostatic potential of decellularized ECM hydrogels
Publication date: Available online 6 August 2018Source: Materials LettersAuthor(s): Reiza D. Ventura, Andrew R. Padalhin, Byong Taek LeeAbstractExtracellular matrix (ECM) hydrogels with a porous microstructure and good swelling behavior were fabricated via lyophilization and cross-linked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC). Platelet adhesion studies revealed that platelets easily adhered to hydrogels while coagulation studies showed rapid blood aggregate formation. In-vitro cytotoxicity studies showed ECM hydrogels are biocompatible. In-vivo studies using rat tail bleeding and rabbit arterial injury ...
Source: Materials Letters - August 7, 2018 Category: Materials Science Source Type: research

Porous chitosan microspheres containing zinc ion for enhanced thrombosis and hemostasis
Publication date: 1 April 2018 Source:Materials Science and Engineering: C, Volume 85 Author(s): Meng Pan, Zonghao Tang, Jianbing Tu, Zhengchao Wang, Qinhui Chen, Rongdong Xiao, Haiqing Liu Quick hemostats for non-lethal massive traumatic bleeding in battlefield and civilian accidents are important for reducing mortality and medical costs. Chitosan (CS) has been widely used as a clinic hemostat. To enhance its hemostatic efficiency, Zn2+ in the form of zinc alginate (ZnAlg) was introduced to CS to make porous CS@ZnAlg microspheres with ZnAlg component on the surface. Such microspheres were prepared by successive steps of ...
Source: Materials Science and Engineering: C - December 19, 2017 Category: Materials Science Source Type: research

Zeolite ‐loaded alginate‐chitosan hydrogel beads as a topical hemostat
Journal of Biomedical Materials Research Part B: Applied Biomaterials, EarlyView.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 26, 2017 Category: Materials Science Authors: ParinazFathi , MichaelSikorski , KaterinaChristodoulides , KristenLangan , Yoon SunChoi , MichaelTitcomb , AnjaliGhodasara , OmasiriWonodi , HemiThaker , MertVural , AdamBehrens , PeterKofinas Source Type: research

Porous chitosan microspheres for application as quick in vitro and in vivo hemostat
We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis. Their density, surface area, porosity, water absorption ratio were 0.04–0.06g/cm3, 28.2–31.5m2/g, 98%, and 15.5–23.2g/g, respectively. The surface pore was con...
Source: Materials Science and Engineering: C - April 4, 2017 Category: Materials Science Source Type: research

Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat
In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content. Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT)...
Source: Materials Science and Engineering: C - March 17, 2017 Category: Materials Science Source Type: research

Synthesis and characterization of glutaraldehyde-based crosslinked gelatin as a local hemostat sponge in surgery: An in vitro study.
In this study, preparation and characterization of soft crosslinked gelatin sponge for blood hemostasis application was considered. The effects of gelatin and crosslinker concentrations and altering freeze-drying temperature on sponges' density and structure, water absorption ability and biodegradation, cytotoxicity, mechanical properties and hemostatic effect were investigated. The density measurement indicated that the density of freeze-dried sponges increased when the freezing temperature was lowered. Scanning electron microscope and optical microscope images showed that gelatin sponges had uniform small pores (60 μm) ...
Source: Bio-Medical Materials and Engineering - January 1, 2013 Category: Materials Science Authors: Imani R, Rafienia M, Hojjati Emami S Tags: Biomed Mater Eng Source Type: research