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Non-oxidized cellulose nanofibers as a topical hemostat: in vitro thromboelastometry studies of structure vs function
Publication date: Available online 8 April 2021Source: Carbohydrate PolymersAuthor(s): Elmira Mohamed, Lucy A. Coupland, Philip J. Crispin, Ailene Fitzgerald, David R. Nisbet, Takuya Tsuzuki
Source: Carbohydrate Polymers - April 8, 2021 Category: Biomedical Science Source Type: research

Fabrication of chitosan@calcium alginate microspheres with porous core and compact shell, and application as a quick traumatic hemostat
Publication date: Available online 24 June 2020Source: Carbohydrate PolymersAuthor(s): Xiaowei Wu, Zonghao Tang, Xiaoming Liao, Zhengchao Wang, Haiqing Liu
Source: Carbohydrate Polymers - June 27, 2020 Category: Biomedical Science Source Type: research

In-vitro and in-vivo evaluation of modified sodium starch glycolate for exploring its haemostatic potential
Publication date: Available online 11 February 2020Source: Carbohydrate PolymersAuthor(s): Vineeta Panwar, Jijo Thomas, Anjana Sharma, Vianni Chopra, Swati Kaushik, Ashutosh Kumar, Deepa GhoshAbstractThe control of blood flow from breached blood vessels during surgery or trauma is challenging. With the existing treatment options being either expensive or ineffective, the development of a haemostat that overcome such drawbacks would be beneficial. With an aim to develop an ideal haemostat, the potential of sodium starch glycolate (SSG), a commonly used pharmaceutical disintegrant was modified to obtain porous microparticles...
Source: Carbohydrate Polymers - February 13, 2020 Category: Biomedical Science Source Type: research

Puff Pastry-Like Chitosan/Konjac Glucomannan Matrix with Thrombin-Occupied Microporous Starch Particles as a Composite for Hemostasis
In this study, we produced a puff pastry-like chitosan/konjac glucomannan matrix loaded with thrombin-occupied microporous starch particles to initiate hemostasis. The composite showed a hierarchical porous structure system consisting of porous and rough structures with evenly distributed microporous starch particles. Thrombin was evenly and independently distributed on the microporous starch particles within the hierarchical system and served to accelerate hemostasis. Meanwhile, the composite displayed excellent water absorption capacity, high zeta potential, roughness, and porosity. The composite was found to elicit desi...
Source: Carbohydrate Polymers - January 8, 2020 Category: Biomedical Science Source Type: research

N-Alkylated Chitosan/Graphene Oxide Porous Sponge for Rapid and Effective Hemostasis in Emergency Situations
Publication date: Available online 9 May 2019Source: Carbohydrate PolymersAuthor(s): Ying Zhang, Jing Guan, Jimin Wu, Sheng Ding, Jian Yang, Jianhua Zhang, Anjie Dong, Liandong DengAbstractN-alkylated chitosan (AC) sponges and graphene oxide (GO) sponges are promising candidates for emergency hemostat. However, AC sponges have weak mechanical strength and GO sponges may induce toxicity. To overcome these problems, a series of AC/GO composite spongs (ACGS) were prepared with various ratios (GO/AC, 0%, 5%, 10%, and 20%) using a dilute solution freeze phase separation and drying process. The sponges exhibit excellent absorpti...
Source: Carbohydrate Polymers - May 10, 2019 Category: Biomedical Science Source Type: research

Enhancement of Hemostatic Property of Plant Derived Oxidized Nanocellulose-Silk Fibroin Based Scaffolds by Thrombin Loading
Publication date: Available online 19 December 2018Source: Carbohydrate PolymersAuthor(s): Anha Afrin Shefa, Mirana Taz, Sun Young Lee, Byong-Taek LeeAbstractTo combat post-surgical and traumatic bleeding conditions effective hemostasis is of great importance. The study was designed to investigate the effect of thrombin (Th) loading on hemostatic performance of TEMPO-oxidized cellulose nanofiber (TOCN)-silk fibroin (SF) scaffolds. Addition of SF with TOCN significantly (***P < 0.001) increased blood absorption capacity and improved biocompatibility of TOCN. Thrombin loading potentiated platelet activation and hemostati...
Source: Carbohydrate Polymers - December 21, 2018 Category: Biomedical Science Source Type: research