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Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Funtabulously Frivolous Friday Five 221
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 220. Question 1 The Adverts, a UK punk band in the 1970s wrote the song “Looking through Gary Gilmore’s eyes”. Who is Gary Gilmore and why would two people be looking through his eyes? + Reveal the Funtabulous Answer expand(document.getElementById('...
Source: Life in the Fast Lane - January 5, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five aspergillum Ayahuasca basket case cornea transplant garlic gary gilmore lone star tick meat allergy otomycosis paul simon shaman swimmers ear Source Type: blogs

Funtabulously Frivolous Friday Five 201
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 201, courtesy of Dr Hakan Yaman from RFDS. Question 1 What is the rate of severe permanent TBI in the Asterix comics, 0%, 25%, 50% or 90%? http://www.asterix.com/the-collection/albums/asterix-and-the-picts.html + Reveal the Funtabulous Answer expand(document.getEle...
Source: Life in the Fast Lane - August 10, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five asterix CRP Death dying Felty's syndrome fingernail GCS head injury hospital Pain pencil RA rheumatoid arthritis TBI Source Type: blogs